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Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram

文献类型：期刊论文

作者Qu, Tengfei1; Qi, Yue1; Yu, Shukui1; Du, Zhengde1; Wei, Wei2; Cai, Aoling3,4; Wang, Jie3,4; Nie, Binbin5,6; Liu, Ke1; Gong, Shusheng1
刊名NEUROSCIENCE
出版日期2019-06-01
卷号408页码:31-45
ISSN号0306-4522
关键词amygdala auditory cortex functional neural activities hippocampus resting state functional MRI tinnitus
DOI10.1016/j.neuroscience.2019.03.054
英文摘要Tinnitus is thought to be triggered by aberrant neural activity in the central auditory pathway and is often accompanied by comorbidities of emotional distress and anxiety, which imply maladaptive functional connectivity to limbic structures, such as the amygdala and hippocampus. Tinnitus patients with normal audiograms can also have accompanying anxiety and depression, clinically. To test the role of functional connectivity between the central auditory pathway and limbic structures in patients with tinnitus with normal audiograms, we developed a murine noise-induced tinnitus model with a temporary threshold shift (TTS). Tinnitus mice exhibited reduced auditory brainstem response wave I amplitude, and an enhanced wave IV amplitude and wave IV/I amplitude ratio, as compared with control and non-tinnitus mice. Resting-state functional magnetic resonance imaging (fMRI) was used to identify abnormal connectivity of the amygdala and hippocampus and to determine the relationship with tinnitus characteristics. We found increased fMRI responses with amplitude of low-frequency fluctuation (ALFF) in the auditory cortex and decreased ALFF in the amygdala and hippocampus at day 1, but decreased ALFF in the auditory cortex and increased ALFF in the amygdala at day 28 post-noise exposure in tinnitus mice. Decreased functional connectivity between auditory brain regions and limbic structures was demonstrated at day 28 in tinnitus mice. Therefore, aberrant neural activities in tinnitus mice with TTS involved not only the central auditory pathway, but also limbic structures, and there was maladaptive functional connectivity between the central auditory pathway and limbic structures, such as the amygdala and hippocampus. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS关键词LOW-FREQUENCY FLUCTUATION ; NORMAL-HEARING PATIENTS ; BRAIN-STEM RESPONSE ; RESTING-STATE FMRI ; COCHLEAR NUCLEUS ; NEURAL ACTIVITY ; EVOKED-POTENTIALS ; NETWORK ACTIVITY ; ACOUSTIC TRAUMA ; DEFAULT-MODE
资助项目Beijing Natural Science Foundation[KZ201810025040] ; Beijing Natural Science Foundation[7174291] ; Beijing Education Committee[KZ201810025040] ; National Natural Science Foundation of China[81771016] ; National Natural Science Foundation of China[81770997]
WOS研究方向Neurosciences & Neurology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000470113700004
资助机构Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Education Committee ; Beijing Education Committee ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Education Committee ; Beijing Education Committee ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Education Committee ; Beijing Education Committee ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation ; Beijing Education Committee ; Beijing Education Committee ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.wipm.ac.cn/handle/112942/14407]  
专题中国科学院武汉物理与数学研究所
通讯作者Liu, Ke; Gong, Shusheng
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, 95th Yongan Rd, Beijing 100050, Peoples R China
2.China Med Univ, Dept Otol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China
3.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
4.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
5.Chinese Acad Sci, Beijing Engn Res Ctr Radiog Tech & Equipment, Inst High Energy Phys, Beijing 100049, Peoples R China
6.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qu, Tengfei,Qi, Yue,Yu, Shukui,et al. Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram[J]. NEUROSCIENCE,2019,408:31-45.
APA Qu, Tengfei.,Qi, Yue.,Yu, Shukui.,Du, Zhengde.,Wei, Wei.,...&Gong, Shusheng.(2019).Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram.NEUROSCIENCE,408,31-45.
MLA Qu, Tengfei,et al."Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram".NEUROSCIENCE 408(2019):31-45.

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来源：武汉物理与数学研究所

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