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A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

文献类型：期刊论文

作者Zhang, Yifan1; Bo, Shaowei3; Feng, Tao1; Qin, Xialing1; Wan, Yilin1; Jiang, Shanshan1; Li, Chunxiao1; Lin, Jing1; Wang, Tianfu1; Zhou, Xin2
刊名ADVANCED MATERIALS
出版日期2019-05-01
卷号31期号:21页码:10
关键词BODIPY amphiphiles multimodal imaging nanoemulsion perfluorocarbon photodynamic theranostics
ISSN号0935-9648
DOI10.1002/adma.201806444
英文摘要To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)-boron dipyrromethene amphiphile (PEG-F-54-BODIPY) with 54 fluorine-19 (F-19) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG-F-54-BODIPY). The as-prepared PFH@PEG-F-54-BODIPY can perform architecture-dependent fluorescence/photoacoustic/F-19 magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self-quenching of BODIPY molecules. More interestingly, PFH@PEG-F-54-BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single-dose intravenous injection. The all-in-one photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.
WOS关键词BODIPY DYES ; CANCER ; HYPOXIA ; NANOPARTICLES ; NANOMATERIALS ; NANOCARRIERS ; TOXICITY ; DELIVERY ; ALBUMIN ; DESIGN
资助项目Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China[161032] ; Basic Research Program of Shenzhen[JCYJ20170412111100742] ; China Postdoctoral Science Foundation[2018M633138] ; National Natural Science Foundation of China[51573096] ; National Natural Science Foundation of China[31771036] ; National Natural Science Foundation of China[51703132] ; National Natural Science Foundation of China[21572168] ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project[2018B030308003] ; National Key Research and Development Program of China[2016YFC1304704]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000474801000004
出版者WILEY-V C H VERLAG GMBH
资助机构Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China ; Basic Research Program of Shenzhen ; Basic Research Program of Shenzhen ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project ; National Key Research and Development Program of China ; National Key Research and Development Program of China
源URL[http://ir.wipm.ac.cn/handle/112942/14574]  
专题中国科学院武汉物理与数学研究所
通讯作者Jiang, Zhong-Xing; Huang, Peng
作者单位1.Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasoun, Lab Evolutionary Theranost, Sch Biomed Engn,Hlth Sci Ctr, Shenzhen 518060, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
3.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yifan,Bo, Shaowei,Feng, Tao,et al. A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy[J]. ADVANCED MATERIALS,2019,31(21):10.
APA Zhang, Yifan.,Bo, Shaowei.,Feng, Tao.,Qin, Xialing.,Wan, Yilin.,...&Huang, Peng.(2019).A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy.ADVANCED MATERIALS,31(21),10.
MLA Zhang, Yifan,et al."A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy".ADVANCED MATERIALS 31.21(2019):10.

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来源：武汉物理与数学研究所

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