Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers
文献类型：期刊论文
| 作者 | Wen, Pengjie1,2; Rao, Xiaoping2; Xu, Liuying3; Zhang, Zhijian2; Jia, Fan2; He, Xiaobin2; Xu, Fuqiang2,4 |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 35期号:4页码:709-723 |
| ISSN号 | 1673-7067 |
| 关键词 | Centrifugal afferents Olfactory bulb Glomerular layer Neurotropic virus Trans-synaptic labeling |
| DOI | 10.1007/s12264-019-00385-6 |
| 英文摘要 | Sensory processing is strongly modulated by different brain and behavioral states, and this is based on the top-down modulation. In the olfactory system, local neural circuits in the olfactory bulb (OB) are innervated by centrifugal afferents in order to regulate the processing of olfactory information in the OB under different behavioral states. The purpose of the present study was to explore the organization of neural networks in olfactory-related cortices and modulatory nuclei that give rise to direct and indirect innervations to the glomerular layer (GL) of the OB at the whole-brain scale. Injection of different recombinant attenuated neurotropic viruses into the GL showed that it received direct inputs from each layer in the OB, centrifugal inputs from the ipsilateralanterior olfactory nucleus (AON), anterior piriform cortex (Pir), and horizontal limb of diagonal band of Broca (HDB), and various indirect inputs from bilateral cortical neurons in the AON, Pir, amygdala, entorhinal cortex, hippocampus, HDB, dorsal raphe, median raphe and locuscoeruleus. These results provide a circuitry basis that will help further understand the mechanism by which olfactory information-processing in the OB is regulated. |
| WOS关键词 | SHORT-AXON CELLS ; NORADRENERGIC MODULATION ; SEROTONERGIC MODULATION ; ENTORHINAL CORTEX ; NEURAL CIRCUITS ; MAMMALIAN MAIN ; ODOR DETECTION ; GRANULE CELLS ; MITRAL CELLS ; INHIBITION |
| 资助项目 | National Natural Science Foundation of China[31400946] ; National Natural Science Foundation of China[31671120] ; National Natural Science Foundation of China[31771197] ; National Natural Science Foundation of China[31329001] ; National Natural Science Foundation of China[31771156] ; National Natural Science Foundation of China[91632303] ; National Natural Science Foundation of China[81661148053/H09] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32030200] ; National Basic Research Development Program (973 Program) of China[2015CB755600] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000475707300013 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; Strategic Priority Research Program of Chinese Academy of Science ; National Basic Research Development Program (973 Program) of China ; National Basic Research Development Program (973 Program) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; Strategic Priority Research Program of Chinese Academy of Science ; National Basic Research Development Program (973 Program) of China ; National Basic Research Development Program (973 Program) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; Strategic Priority Research Program of Chinese Academy of Science ; National Basic Research Development Program (973 Program) of China ; National Basic Research Development Program (973 Program) of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; Strategic Priority Research Program of Chinese Academy of Science ; National Basic Research Development Program (973 Program) of China ; National Basic Research Development Program (973 Program) of China |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14752]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | He, Xiaobin; Xu, Fuqiang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligent Technol,St, Key Lab Magnet Resonance Biol Syst,Ctr Brain Sci, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Hubei, Peoples R China 3.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China 4.Wuhan Natl Lab Optoelect, Div Biomed Photon, Wuhan 430074, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Pengjie,Rao, Xiaoping,Xu, Liuying,et al. Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers[J]. NEUROSCIENCE BULLETIN,2019,35(4):709-723. |
| APA | Wen, Pengjie.,Rao, Xiaoping.,Xu, Liuying.,Zhang, Zhijian.,Jia, Fan.,...&Xu, Fuqiang.(2019).Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers.NEUROSCIENCE BULLETIN,35(4),709-723. |
| MLA | Wen, Pengjie,et al."Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers".NEUROSCIENCE BULLETIN 35.4(2019):709-723. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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