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A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses

文献类型：期刊论文

作者Zhou, Zheng1,5,6; Liu, Xuemei1,5,6; Chen, Shanping1,5,6; Zhang, Zhijian2,7; Liu, Yuanming5,6; Montardy, Quentin5,6; Tang, Yongqiang1,5,6; Wei, Pengfei5,6; Liu, Nan1,5,6; Li, Lei5,6
刊名NEURON
出版日期2019-08-07
卷号103期号:3页码:473-+
ISSN号0896-6273
DOI10.1016/j.neuron.2019.05.027
英文摘要Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTA(GABA+) neurons respond to a looming stimulus. Inhibition of VTA(GABA+) neurons reduced looming- evoked defensive flight behavior, and photo-activation of these neurons resulted in defense-like flight behavior. Using viral tracing and electrophysiological recordings, we show that VTA(GABA+) neurons receive direct excitatory inputs from the superior colliculus (SC). Furthermore, we show that glutamatergic SC-VTA projections synapse onto VTA(GABA+) neurons that project to the central nucleus of the amygdala (CeA) and that the CeA is involved in mediating the defensive behavior. Our findings demonstrate that aerial threat- related visual information is relayed to VTA(GABA+) neurons mediating innate behavioral responses, suggesting a more general role of the VTA.
WOS关键词DISINHIBITS DOPAMINE NEURONS ; SUPERIOR COLLICULUS ; LATERAL HYPOTHALAMUS ; INHIBITORY CIRCUIT ; GABA NEURONS ; AMYGDALA ; REWARD ; INPUT ; FEAR ; PROJECTIONS
资助项目National Natural Science Foundation of China (NSFC)[31630031] ; NSFC[81425010] ; NSFC[31471109] ; NSFC[31671116] ; NSFC[91632303/H09] ; NSFC[91732304] ; NSFC[31500861] ; International Partnership Program of Chinese Academy of Sciences[172644KYS820170004] ; Helmholtz-CAS joint research grant[GJHZ1508] ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior[2017B030301017] ; Shenzhen government[JCYJ20160429190927063] ; Shenzhen government[KQJSCX20160301144002] ; Shenzhen government[JCYJ20170413164535041] ; Shenzhen government[JCYJ20150401150223647] ; Research Instrument Development Project of the Chinese Academy of Sciences[YJKYYQ20170064] ; Youth Innovation Promotion Association[CAS 2017413] ; Youth Innovation Promotion Association[JSGG20160429190521240] ; Shenzhen Municipal Funding[GJHZ20160229200136090] ; Shenzhen Discipline Construction Project for Neurobiology[DRCSM [2016] 1379] ; Ten Thousand Talent Program ; Guangdong Special Support Program ; Science and Technology Planning Project of Guangdong Province[2018B030331001]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000479119400015
出版者CELL PRESS
资助机构National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; NSFC ; NSFC ; International Partnership Program of Chinese Academy of Sciences ; International Partnership Program of Chinese Academy of Sciences ; Helmholtz-CAS joint research grant ; Helmholtz-CAS joint research grant ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Shenzhen government ; Shenzhen government ; Research Instrument Development Project of the Chinese Academy of Sciences ; Research Instrument Development Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Shenzhen Municipal Funding ; Shenzhen Municipal Funding ; Shenzhen Discipline Construction Project for Neurobiology ; Shenzhen Discipline Construction Project for Neurobiology ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; Guangdong Special Support Program ; Guangdong Special Support Program ; Science and Technology Planning Project of Guangdong Province ; Science and Technology Planning Project of Guangdong Province ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; NSFC ; NSFC ; International Partnership Program of Chinese Academy of Sciences ; International Partnership Program of Chinese Academy of Sciences ; Helmholtz-CAS joint research grant ; Helmholtz-CAS joint research grant ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Shenzhen government ; Shenzhen government ; Research Instrument Development Project of the Chinese Academy of Sciences ; Research Instrument Development Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Shenzhen Municipal Funding ; Shenzhen Municipal Funding ; Shenzhen Discipline Construction Project for Neurobiology ; Shenzhen Discipline Construction Project for Neurobiology ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; Guangdong Special Support Program ; Guangdong Special Support Program ; Science and Technology Planning Project of Guangdong Province ; Science and Technology Planning Project of Guangdong Province ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; NSFC ; NSFC ; International Partnership Program of Chinese Academy of Sciences ; International Partnership Program of Chinese Academy of Sciences ; Helmholtz-CAS joint research grant ; Helmholtz-CAS joint research grant ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Shenzhen government ; Shenzhen government ; Research Instrument Development Project of the Chinese Academy of Sciences ; Research Instrument Development Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Shenzhen Municipal Funding ; Shenzhen Municipal Funding ; Shenzhen Discipline Construction Project for Neurobiology ; Shenzhen Discipline Construction Project for Neurobiology ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; Guangdong Special Support Program ; Guangdong Special Support Program ; Science and Technology Planning Project of Guangdong Province ; Science and Technology Planning Project of Guangdong Province ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; NSFC ; NSFC ; International Partnership Program of Chinese Academy of Sciences ; International Partnership Program of Chinese Academy of Sciences ; Helmholtz-CAS joint research grant ; Helmholtz-CAS joint research grant ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior ; Shenzhen government ; Shenzhen government ; Research Instrument Development Project of the Chinese Academy of Sciences ; Research Instrument Development Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Shenzhen Municipal Funding ; Shenzhen Municipal Funding ; Shenzhen Discipline Construction Project for Neurobiology ; Shenzhen Discipline Construction Project for Neurobiology ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; Guangdong Special Support Program ; Guangdong Special Support Program ; Science and Technology Planning Project of Guangdong Province ; Science and Technology Planning Project of Guangdong Province
源URL[http://ir.wipm.ac.cn/handle/112942/14793]  
专题中国科学院武汉物理与数学研究所
通讯作者Xu, Fuqiang; Wang, Liping
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
4.MIT, Dept Brain & Cognit Sci, McGovern Inst Brain Res, E25-618, Cambridge, MA 02139 USA
5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shenzhen Fundamental Res Inst,Shenzhen Key Lab Ne, BCBDI,Shenzhen Inst Adv Technol,Shenzhen Hong Kon, Shenzhen 518055, Peoples R China
6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shenzhen Inst Adv Technol,Collaborat Innovat Ctr, BCBDI,Shenzhen Hong Kong Inst Brain Sci,Shenzhen, Shenzhen 518055, Peoples R China
7.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Wuhan Inst Phys & Math, Ctr Brain Sci,Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Zheng,Liu, Xuemei,Chen, Shanping,et al. A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses[J]. NEURON,2019,103(3):473-+.
APA Zhou, Zheng.,Liu, Xuemei.,Chen, Shanping.,Zhang, Zhijian.,Liu, Yuanming.,...&Wang, Liping.(2019).A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses.NEURON,103(3),473-+.
MLA Zhou, Zheng,et al."A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses".NEURON 103.3(2019):473-+.

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来源：武汉物理与数学研究所

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