Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration
文献类型：期刊论文
| 作者 | Jiang, Zhiming1; Lin, Chenghong1; Liu, Huili2; Feng, Jianghua1; Zheng, Zhenyao1; Cai, Shuhui1 |
| 刊名 | NANOMEDICINE
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 14期号:11页码:1371-1386 |
| 关键词 | biological response contrast agent metabolomic analysis NMR spectroscopy nuclear magnetic resonance ultra-small superparamagnetic particles of iron oxides USPIO |
| ISSN号 | 1743-5889 |
| DOI | 10.2217/nnm-2018-0433 |
| 英文摘要 | Aim: The potential bio-related risks of dextran-coated ultra-small superparamagnetic particles of iron oxides (D-USPIO) were assessed. Materials & methods: Metabolic responses of D-USPIO in BALB/C mice were obtained using H-1-NMR-based metabolomic strategy combined with the traditional biochemical assay. Results: The metabolomic analyses of biological fluids (plasma and urine) and organs (liver, kidney and spleen) indicated that the disturbance, impairment and recovery of the physiological functions were related to the metabolic response to D-USPIO. The correlations between the biofluids and tissue metabolomes described the specific metabolic information of D-USPIO on their in vivo transportation, absorption, biodistribution and excretion. Conclusion: Metabolomic analysis provides preliminary validation for the use of D-USPIO in clinical medicine, and the results help to understand the potential adverse effects of the similar bio-nanomaterials further serve to their synthesis optimization and biocompatibility improvement. |
| WOS关键词 | LIVER-CIRRHOSIS ; NANOPARTICLES ; PHENYLALANINE ; TAURINE ; USPIO ; METABOLISM ; DISEASE ; RATS |
| 资助项目 | National Natural Science Foundation of China[31671920] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000479157200002 |
| 出版者 | FUTURE MEDICINE LTD |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14810]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Feng, Jianghua |
| 作者单位 | 1.Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Fujian, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhiming,Lin, Chenghong,Liu, Huili,et al. Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration[J]. NANOMEDICINE,2019,14(11):1371-1386. |
| APA | Jiang, Zhiming,Lin, Chenghong,Liu, Huili,Feng, Jianghua,Zheng, Zhenyao,&Cai, Shuhui.(2019).Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration.NANOMEDICINE,14(11),1371-1386. |
| MLA | Jiang, Zhiming,et al."Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration".NANOMEDICINE 14.11(2019):1371-1386. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。