Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex
文献类型:期刊论文
作者 | Zou, Yijuan1,2; Zhang, Hui2; Chen, Xi2; Ji, Wenliang3; Mao, Lanqun3; Lei, Hao1,2 |
刊名 | NEUROCHEMISTRY INTERNATIONAL |
出版日期 | 2019-10-01 |
卷号 | 129页码:11 |
ISSN号 | 0197-0186 |
DOI | 10.1016/j.neuint.2019.104503 |
英文摘要 | NMDAR antagonist treatments in adolescent/young adult rodents are associated with augmented glutamate (Glu) release and perturbed Glu/glutamine (Gin) metabolism in the medial prefrontal cortex (mPFC) resembling those found in first-episode schizophrenia. Few studies, however, investigated NMDAR antagonist induced changes in the adult mPFC and whether there is an age-dependence to this end. In this study, the effects of acute/repeated (+)-MK801 treatment on Glu release/metabolism were measured in the mPFC of male adolescent (postnatal day 30) and adult (14 weeks) rats. Acute (+)-MK801 treatment at 0.5 mg/kg body weight induced an approximately 4-fold increase of extracellular Glu concentration in the adolescent rats, and repeated treatment for 6 consecutive days significantly increased the levels of Glu + Gln (Glx) and glial metabolites 7 days after the last dose. Histologically (+)-MK801 treatments induced reactive astrocytosis and elevated oxidative stress in the mPFC of adolescent rats, without causing evident neuronal degeneration in the region. All (+)-MK801-induced changes observed in the mPFC of adolescent rats were not present or evident in the adult rats, suggesting that the treatments might have caused less disinhibition in the adult mPFC than in the adolescent mPFC. In conclusion, the effects of (+)-MK801 treatments on the Glu release/metabolism in the mPFC were found to be age-dependent; and the adult mPFC is likely equipped with more robust neurobiological mechanisms to preserve excitatory-inhibitory balance in response to NMDAR hypofunction. |
WOS关键词 | METHYL-D-ASPARTATE ; GAMMA-AMINOBUTYRIC-ACID ; NMDA RECEPTOR ANTAGONISTS ; FAST-SPIKING INTERNEURONS ; IN-VIVO ; EXTRACELLULAR GLUTAMATE ; PROTON MRS ; ANTICONVULSANT MK-801 ; PROLONGED EXPOSURE ; KETAMINE MODEL |
资助项目 | Natural Science Foundation of China[21790390] ; Natural Science Foundation of China[21790392] ; K. C. Wong Educational Foundation |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000483908300044 |
资助机构 | Natural Science Foundation of China ; Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation |
源URL | [http://ir.wipm.ac.cn/handle/112942/14892] |
专题 | 中国科学院武汉物理与数学研究所 |
通讯作者 | Lei, Hao |
作者单位 | 1.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan 430071, Hubei, Peoples R China 3.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Zou, Yijuan,Zhang, Hui,Chen, Xi,et al. Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex[J]. NEUROCHEMISTRY INTERNATIONAL,2019,129:11. |
APA | Zou, Yijuan,Zhang, Hui,Chen, Xi,Ji, Wenliang,Mao, Lanqun,&Lei, Hao.(2019).Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex.NEUROCHEMISTRY INTERNATIONAL,129,11. |
MLA | Zou, Yijuan,et al."Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex".NEUROCHEMISTRY INTERNATIONAL 129(2019):11. |
入库方式: OAI收割
来源:武汉物理与数学研究所
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