Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)
文献类型：期刊论文
| 作者 | Tian, Yuan2,3; Gui, Wei2; Smith, Philip B.1; Koo, Imhoi2; Murray, Lain A.2; Cantorna, Margherita T.2; Perdew, Gary H.2; Patterson, Andrew D.2 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2019-08-21 |
| 卷号 | 67期号:33页码:9286-9294 |
| 关键词 | white buttom mushroom aryl hydrocarbon ligand mass spectrometry |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.9b03212 |
| 英文摘要 | Natural aryl hydrocarbon (AHR) ligands have been identified in food and herbal medicines, and they may exhibit beneficial activity in humans. In this study, white button (WB) feeding significantly decreased AHR target gene expression in the small intestine of both conventional and germ-free mice. High-performance liquid chromatography (HPLC) fractionation and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) combined with an AHR-responsive cell-based luciferase gene reporter assay were used to isolate and characterize benzothiazole (BT) derivatives and 6-methylisoquinoline (6-MIQ) as AHR modulators from WB mushrooms. The study showed dose-dependent changes of AHR transformation determined by the cell-based luciferase gene reporter assay and transcription of CYPIA1 in human Caco-2 cells by BT derivatives and 6-MIQ These findings suggested that WB mushroom contains new classes of natural AHR modulators and demonstrated HPLC fractionation and UHPLC-MS/MS combined with a cell-based luciferase gene reporter assay as a useful approach for isolation and characterization of the previously unidentifed AHR modulators from natural products. |
| WOS关键词 | MASS SPECTROMETRY ; DERIVATIVES ; AHR ; BENZOTHIAZOLE ; QUINOLINE ; LIGANDS ; INHIBITION ; METABOLISM ; FLAVONOIDS ; OBESITY |
| 资助项目 | National Institutes of Health[ES028288] ; National Institutes of Health[ES026684] ; National Institutes of Health[ES028244] ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations[PEN04607] ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations[1009993] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000482546200017 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14905]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Patterson, Andrew D. |
| 作者单位 | 1.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA 2.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA 3.Univ Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, CAS,Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Ph, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yuan,Gui, Wei,Smith, Philip B.,et al. Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(33):9286-9294. |
| APA | Tian, Yuan.,Gui, Wei.,Smith, Philip B..,Koo, Imhoi.,Murray, Lain A..,...&Patterson, Andrew D..(2019).Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(33),9286-9294. |
| MLA | Tian, Yuan,et al."Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.33(2019):9286-9294. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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