Stimulated phospholipid synthesis is key for hepatitis B virus replications
文献类型：期刊论文
| 作者 | Huang, Qingxia1,2; Lei, Hehua2; Ding, Laifeng1,2; Wang, Yulan3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019-09-10 |
| 卷号 | 9页码:9 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-019-49367-8 |
| 英文摘要 | Chronic hepatitis B Virus (HBV) infection has high morbidity, high pathogenicity and unclear pathogenesis. To elucidate the relationship between HBV replication and host phospholipid metabolites, we measured 10 classes of phospholipids in serum of HBV infected patients and cells using ultra performance liquid chromatograph-triple quadruple mass spectrometry. We found that the levels of phosphatidylcholine (PC), phosphatidylethanolamine, and lyso-phosphatidic acid were increased in HBsAg (+) serum of infected patients compared with HBsAg (-), while phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin were decreased, which were confirmed in an HBV infected HepG2.2.15 cell line. We further evaluated the enzyme levels of PC pathways and found that PCYT1A and LPP1 for PC synthesis were up-regulated after HBV infection. Moreover, HBV replication was inhibited when PCYT1A and LPP1 were inhibited. These results indicated that the PC synthesis in HBV infected host are regulated by PCYT1A and LPP1, which suggests that PCYT1A, LPP1 could be new potential targets for HBV treatment. |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA ; CELL ; ANTIGEN ; BIOSYNTHESIS ; EPIDEMIOLOGY ; INHIBITION ; ACTIVATION ; MECHANISMS ; PARTICLES ; RNAI |
| 资助项目 | National Key R&D Program of China[2017YFC0906800] ; National Science Foundation of China[21675169] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000484986300003 |
| 出版者 | NATURE PUBLISHING GROUP |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14951]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Wang, Yulan |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math,Key Lab Magnet Resonance B, Wuhan 430071, Hubei, Peoples R China 3.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore Phenome Ctr, 59 Nanyang Dr, Singapore, Singapore |
| 推荐引用方式 GB/T 7714 | Huang, Qingxia,Lei, Hehua,Ding, Laifeng,et al. Stimulated phospholipid synthesis is key for hepatitis B virus replications[J]. SCIENTIFIC REPORTS,2019,9:9. |
| APA | Huang, Qingxia,Lei, Hehua,Ding, Laifeng,&Wang, Yulan.(2019).Stimulated phospholipid synthesis is key for hepatitis B virus replications.SCIENTIFIC REPORTS,9,9. |
| MLA | Huang, Qingxia,et al."Stimulated phospholipid synthesis is key for hepatitis B virus replications".SCIENTIFIC REPORTS 9(2019):9. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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