japaneseencephalitisvirusns1proteinantagonizesinterferonbetaproduction
文献类型：期刊论文
| 作者 | Dengyuan Zhou1; Fan Jia2; Qiuyan Li1; Luping Zhang1; Zheng Chen1; Zikai Zhao1; Min Cui1; Yunfeng Song1; Huanchun Chen1; Shengbo Cao1 |
| 刊名 | 中国病毒学英文版
 |
| 出版日期 | 2018 |
| 卷号 | 000期号:006页码:515 |
| ISSN号 | 1674-0769 |
| 英文摘要 | Japanese encephalitis virus(JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1’, a52-amino acid C-terminal extension of NS1, is generated with a-1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1’ plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1’ defected(rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus(pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type Ⅰ interferon(IFN) response than that by pSA14, and JEV NS1’ significantly inhibited the production of IFN-b and IFN-stimulated genes. Taken together, our results reveal that NS1’ plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication. |
| 资助项目 | [National Key Research and Development Program of China] ; [National Natural Science Foundation of China] ; [Fundamental Research Funds for the Central Universities] |
| 语种 | 英语 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/15240]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 作者单位 | 1.State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University 2.中国科学院武汉物理与数学研究所 3.The Cooperative Innovation Center for Sustainable Pig Production,Huazhong Agricultural University 4.Key Laboratory of Preventive Veterinary Medicine in Hubei Province,College of Veterinary Medicine,Huazhong Agricultural University |
| 推荐引用方式 GB/T 7714 | Dengyuan Zhou,Fan Jia,Qiuyan Li,et al. japaneseencephalitisvirusns1proteinantagonizesinterferonbetaproduction[J]. 中国病毒学英文版,2018,000(006):515. |
| APA | Dengyuan Zhou.,Fan Jia.,Qiuyan Li.,Luping Zhang.,Zheng Chen.,...&Jing Ye.(2018).japaneseencephalitisvirusns1proteinantagonizesinterferonbetaproduction.中国病毒学英文版,000(006),515. |
| MLA | Dengyuan Zhou,et al."japaneseencephalitisvirusns1proteinantagonizesinterferonbetaproduction".中国病毒学英文版 000.006(2018):515. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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