correlativeanalysisofneoplasmpatientswithphlegmstasis痰瘀orabnormalsavda异常黑胆质syndromebasedonmetabonomics
文献类型：期刊论文
| 作者 | Batur Mamtimin1; Halmurat Upur1; Hao Fuhua2 ; Rena Aiziz3; Aynur Matsidik3
|
| 刊名 | journaloftraditionalchinesemedicine
 |
| 出版日期 | 2012 |
| 卷号 | 032期号:001页码:119 |
| ISSN号 | 0255-2922 |
| 英文摘要 | OBJECTIVE：To investigate plasma samples from neoplasm patients with phlegm-stasis or abnormal Savda syndrome,with NMR spectroscopy,and to analyze their metabolic varieties,characteristics and reciprocity.METHODS：1 H-NMR spectra were analyzed using the orthogonal projection to latent structure with discriminative analysis（OPLS-DA） method with unit variance scaling.The discriminative significance of metabolites was determined by the Pearson＇s product-moment correlation coefficient.RESULTS：Compared to the control group,neoplasm patients with phlegm-stasis or abnormal Savda syndrome had low concentrations of leucine,isoleucine,valine,alanine,tyrosine,histidine,citrul-line,glycoprotein,glutamine,myo-inositol,scyllo-inositol,creatine,α-glucose,β-glucose and lactate（P0.05）,and high concentrations of very low density lipoprotein,low density lipoprotein,unsaturated lipid,formate,acetone,acetate,acetoacetate,pyruvate,β-hydroxybutyrate,carnitine and malonic acid（P0.05）,with no significant differences between the phlegm-stasis and abnormal Savda syndrome patients.CONCLUSIONS：Neoplasm patients with different syndromes have very similar metabolic changes.A series of abnormalities such as immune dysfunction and oxidative-antioxidative imbalance,occur in neoplasm patients with abnormal Savda or phlegm-stasis syndrome. |
| 语种 | 英语 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/18211]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 作者单位 | 1.College of Pharmacy,Xinjiang Medical University 2.中国科学院武汉物理与数学研究所 3.Faculty of Traditional Uyghur Medicine,Xinjiang Medica lUniversity |
| 推荐引用方式 GB/T 7714 | Batur Mamtimin,Halmurat Upur,Hao Fuhua,等. correlativeanalysisofneoplasmpatientswithphlegmstasis痰瘀orabnormalsavda异常黑胆质syndromebasedonmetabonomics[J]. journaloftraditionalchinesemedicine,2012,032(001):119. |
| APA | Batur Mamtimin,Halmurat Upur,Hao Fuhua,Rena Aiziz,&Aynur Matsidik.(2012).correlativeanalysisofneoplasmpatientswithphlegmstasis痰瘀orabnormalsavda异常黑胆质syndromebasedonmetabonomics.journaloftraditionalchinesemedicine,032(001),119. |
| MLA | Batur Mamtimin,et al."correlativeanalysisofneoplasmpatientswithphlegmstasis痰瘀orabnormalsavda异常黑胆质syndromebasedonmetabonomics".journaloftraditionalchinesemedicine 032.001(2012):119. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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