ahighlyefficientandtumorvasculartargetingtherapeutictechniquewithsizeexpansiblegadofullerenenanocrystals
文献类型：期刊论文
| 作者 | Zhen Mingming3; Shu Chunying3; Li Jie3; Zhang Guoqiang3; Wang Taishan3; Luo Yi2; Zou Toujun3; Deng Ruijun3; Fang Fang1; Lei Hao1 |
| 刊名 | sciencechinamaterials
 |
| 出版日期 | 2015 |
| 卷号 | 58期号:10页码:799 |
| ISSN号 | 2095-8226 |
| 英文摘要 | It has long been a dream to achieve tumor targeting therapy that can efficiently reduce the toxicity and severe side effects of conventional antitumor chemotherapeutic agents. Taking advantage of the abnormalities of tumor vasculature, we demonstrate here a new powerful tumor vascular-targeting therapeutic technique for solid cancers that applies advanced nanotechnology to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels. Water soluble magnetic Gd@C_(82) nanocrystals of the chosen sizes are deliberately designed with abilities to penetrate into the leaky tumor blood vessels. By triggering the radiofrequency induced phase transition of gadofullerene nanocrystals while extravasating the tumor blood vessel, the explosive structural change of nanoparticles generates a devastating impact on abnormal tumor blood vessels, resulting in a rapid and extensive ischemia necrosis and shrinkage of the tumors. This unprecedented target-specific physiotherapy is found to work perfectly for advanced and refractory solid tumors. |
| 语种 | 英语 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/20088]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 作者单位 | 1.中国科学院武汉物理与数学研究所 2.中国科学技术大学 3.中国科学院化学研究所 |
| 推荐引用方式 GB/T 7714 | Zhen Mingming,Shu Chunying,Li Jie,et al. ahighlyefficientandtumorvasculartargetingtherapeutictechniquewithsizeexpansiblegadofullerenenanocrystals[J]. sciencechinamaterials,2015,58(10):799. |
| APA | Zhen Mingming.,Shu Chunying.,Li Jie.,Zhang Guoqiang.,Wang Taishan.,...&Bai Chunli.(2015).ahighlyefficientandtumorvasculartargetingtherapeutictechniquewithsizeexpansiblegadofullerenenanocrystals.sciencechinamaterials,58(10),799. |
| MLA | Zhen Mingming,et al."ahighlyefficientandtumorvasculartargetingtherapeutictechniquewithsizeexpansiblegadofullerenenanocrystals".sciencechinamaterials 58.10(2015):799. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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