activationofparvalbumininterneuronsinanteriorcingulatecorteximpairsobservationalfear
文献类型：期刊论文
| 作者 | Zhou Chunran3; Zhou Zheng3; Han Yushui2; Lei Zhuogui3; Li Lei3; Montardy Quentin3; Liu Xuemei3; Xu Fuqiang1; Wang Liping3 |
| 刊名 | sciencebulletin
 |
| 出版日期 | 2018 |
| 卷号 | 63期号:12页码:771 |
| ISSN号 | 2095-9273 |
| 英文摘要 | The ability to detect conspecific’s distress is crucial for animal survival. In rodent models, observational fear (OF) occurs when one animal perceives another fear related negative emotions, which may model certain behaviors caused by witnessing traumatic experiences in humans. Anterior cingulate cortex (ACC) has been showed to play a crucial role in OF. However, cellular and neural circuit basis relating to ACC governing OF is poorly understood. Here, we used Designer Receptor Exclusively Activated by a Designer Drug (DREADD) system to investigate the cell type specific circuit mechanism of ACC in OF. Firstly, inhibitory hM4D (Gi) designer receptor together with clozapine N-oxide (CNO) injection was applied to inactivate ACC neurons in the observer mice. We found that, chemogenetic inhibition of ACC resulted in a decreased freezing response in the observer mice. Next, combining PV-ires-Cre mice and Cre-dependent DREADD system, we selectively targeted the ACC parvalbumin (PV) interneurons with the excitatory hM3D (Gq) designer receptor. Activation of ACC PV interneurons following CNO injection reduced freezing response in the observer mice, while had no effect on freezing response in the demonstrator mice. Finally, monosynaptic rabies retrograde tracing revealed that ACC PV interneurons receive inputs from the mediodorsal thalamic nucleus (MD) and the ventromedial thalamic nucleus (VM), both known for their roles in OF. Taken together, these findings reveal that ACC activation is important for OF, during which PV interneurons in ACC play an important regulatory role. Abnormal function of ACC PV interneurons might contribute to the pathology of empathy- deficits related diseases, such as autism and schizophrenia. |
| 语种 | 英语 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/20469]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 作者单位 | 1.中国科学院武汉物理与数学研究所 2.南方医科大学 3.中国科学院深圳先进技术研究院 |
| 推荐引用方式 GB/T 7714 | Zhou Chunran,Zhou Zheng,Han Yushui,et al. activationofparvalbumininterneuronsinanteriorcingulatecorteximpairsobservationalfear[J]. sciencebulletin,2018,63(12):771. |
| APA | Zhou Chunran.,Zhou Zheng.,Han Yushui.,Lei Zhuogui.,Li Lei.,...&Wang Liping.(2018).activationofparvalbumininterneuronsinanteriorcingulatecorteximpairsobservationalfear.sciencebulletin,63(12),771. |
| MLA | Zhou Chunran,et al."activationofparvalbumininterneuronsinanteriorcingulatecorteximpairsobservationalfear".sciencebulletin 63.12(2018):771. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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