correlationofbehaviorchangesandboldsignalinalzheimerlikeratmodel
文献类型：期刊论文
| 作者 | Hu Zhenghui4; Wang Xiaochuan3; Li Liyun3; Liu Maili3; Liu Rong2; Ling Zhiqun2; Tian Qing2; Tang Xiaowei4; Wu Yigen1; Wang Jianzhi2 |
| 刊名 | actabiochimicaetbiophysicasinica
 |
| 出版日期 | 2004 |
| 卷号 | 36期号:12页码:803 |
| ISSN号 | 1672-9145 |
| 英文摘要 | To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser(396)/Ser(404) and Ser(199)/Ser(202) was significantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation. |
| 语种 | 英语 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/21267]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 作者单位 | 1.中国科学院高能物理研究所 2.华中科技大学同济医学院 3.中国科学院武汉物理与数学研究所 4.浙江大学 |
| 推荐引用方式 GB/T 7714 | Hu Zhenghui,Wang Xiaochuan,Li Liyun,et al. correlationofbehaviorchangesandboldsignalinalzheimerlikeratmodel[J]. actabiochimicaetbiophysicasinica,2004,36(12):803. |
| APA | Hu Zhenghui.,Wang Xiaochuan.,Li Liyun.,Liu Maili.,Liu Rong.,...&Wang Jianzhi.(2004).correlationofbehaviorchangesandboldsignalinalzheimerlikeratmodel.actabiochimicaetbiophysicasinica,36(12),803. |
| MLA | Hu Zhenghui,et al."correlationofbehaviorchangesandboldsignalinalzheimerlikeratmodel".actabiochimicaetbiophysicasinica 36.12(2004):803. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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