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Morphology of Osteogenesis Imperfecta Collagen Mimetic Peptide Assemblies Correlates with the Identity of Glycine-Substituting Residue

文献类型：期刊论文

作者Yao, Linyan2; Liu, Zhao2; Yu, Jingyuan2; Luo, Liting1; Wang, Jie1; Xiao, Jianxi2
刊名CHEMBIOCHEM
出版日期2019-10-01
页码8
关键词collagen mimetic peptides morphology mutations osteogenesis imperfecta triple helices
ISSN号1439-4227
DOI10.1002/cbic.201900114
英文摘要Osteogenesis imperfecta (OI) is a hereditary bone disorder with various phenotypes ranging from mild multiple fractures to perinatal lethal cases, and it mainly results from the substitution of Gly by a bulkier residue in type I collagen. Triple-helical peptide models of Gly mutations have been widely utilized to decipher the etiology of OI, although these studies are mainly limited to characterizing the peptide features, such as stability and conformation in the solution state. Herein, we have constructed a new series of triple-helical peptides DD(GPO)(5)ZPO(GPO)(4)DD (Z=Ala, Arg, Asp, Cys, Glu, Ser, and Val) mimicking the most common types of observed OI cases. The inclusion of special terminal aspartic acids enables these collagen mimetic peptides to self-assemble to form nanomaterials upon the trigger of lanthanide ions. We have for the first time systematically evaluated the effect of different OI mutations on the aggregated state of collagen mimetic peptides. We have revealed that the identity of the Gly-substituting residue plays a determinant role in the morphology and secondary structure of the collagen peptide assemblies, showing that bulkier residues tend to result in a disruptive secondary structure and defective morphology, which lead to more severe OI phenotypes. These findings of osteogenesis imperfecta collagen mimetic peptides in the aggregation state provide novel perspectives on the molecular mechanism of osteogenesis imperfecta, and may aid the development of new therapeutic strategies.
WOS关键词TRIPLE-HELIX ; I COLLAGEN ; MODEL PEPTIDES ; BINDING SITES ; N-PROTEINASE ; MUTATIONS ; CHAIN ; PROCOLLAGEN ; KINK ; RENUCLEATION
资助项目National Natural Science Foundation of China[21775059] ; Fundamental Research Funds for the Central Universities[lzujbky-2018-78]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000488340400001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
源URL[http://ir.wipm.ac.cn/handle/112942/21399]  
专题中国科学院武汉物理与数学研究所
通讯作者Xiao, Jianxi
作者单位1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
2.Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Yao, Linyan,Liu, Zhao,Yu, Jingyuan,et al. Morphology of Osteogenesis Imperfecta Collagen Mimetic Peptide Assemblies Correlates with the Identity of Glycine-Substituting Residue[J]. CHEMBIOCHEM,2019:8.
APA Yao, Linyan,Liu, Zhao,Yu, Jingyuan,Luo, Liting,Wang, Jie,&Xiao, Jianxi.(2019).Morphology of Osteogenesis Imperfecta Collagen Mimetic Peptide Assemblies Correlates with the Identity of Glycine-Substituting Residue.CHEMBIOCHEM,8.
MLA Yao, Linyan,et al."Morphology of Osteogenesis Imperfecta Collagen Mimetic Peptide Assemblies Correlates with the Identity of Glycine-Substituting Residue".CHEMBIOCHEM (2019):8.

入库方式： OAI收割

来源：武汉物理与数学研究所

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