中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 武汉物理与数学研究所
  3. 中国科学院武汉物理与数学研究所
Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method

文献类型：期刊论文

作者Yang, Jingyu7,8,9; Guo, Huiling7,8,9; Sun, Dandan8,9; Duan, Jia8,9; Rao, Xiaoping6,7; Xu, Fuqiang4,5,6,7; Manyande, Anne3; Tang, Yanqing2,8,9; Wang, Jie1,6,7; Wang, Fei8,9
刊名AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
出版日期2019
卷号11期号:9页码:5919-5931
ISSN号1943-8141
关键词Schizophrenia H-1-NMR glutamate GABA taurine
英文摘要Accumulating evidence suggests that brain metabolic changes may be associated with the pathophysiology of schizophrenia. Both in vivo and in vitro studies have found glutamatergic and GABAergic abnormalities in different brain regions of individuals with schizophrenia. We report a longitudinal behavioral study in a methylazoxymethanol acetate (MAM) rat model of schizophrenia at three different age periods: prepuberty, late-puberty and early-adulthood. MAM-treated rats showed stable hypolocomotive activity, anxiety and cognitive deficits from late-puberty to early-adulthood. Therefore we detected the metabolites changes of adult MAM-treated rats using an in vitro proton nuclear magnetic resonance (H-1-NMR) method. In the MAM-treated rats, glutamate was increased in the thalamus and hypothalamus, glutamine was increased in the hippocampus and GABA was increased in the hippocampus and prefrontal cortex, while taurine showed a decrease in the striatum, temporal cortex and parietal cortex. These abnormalities may be helped further understanding the pathophysiology of schizophrenia.
WOS关键词GAMMA-AMINOBUTYRIC-ACID ; DEVELOPMENTAL DISRUPTION MODEL ; MESSENGER-RNA EXPRESSION ; NMDA RECEPTOR BLOCKADE ; PREFRONTAL CORTEX ; METHYLAZOXYMETHANOL ACETATE ; CEREBROSPINAL-FLUID ; RAT-BRAIN ; GENE-EXPRESSION ; ADULT RATS
资助项目China Postdoctoral Science Foundation[2018M640265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y6Y00-21004]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
出版者E-CENTURY PUBLISHING CORP
WOS记录号WOS:000488232800051
资助机构China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences
源URL[http://ir.wipm.ac.cn/handle/112942/21436]  
专题中国科学院武汉物理与数学研究所
通讯作者Wang, Jie; Wang, Fei
作者单位1.2nd Hosp Shijiazhuang, Shijiazhuang 050051, Hebei, Peoples R China
2.China Med Univ, Affiliated Hosp 1, Dept Geriatr Med, Shenyang, Liaoning, Peoples R China
3.Univ West London, Sch Human & Social Sci, London, England
4.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Hubei, Peoples R China
8.China Med Univ, Affiliated Hosp 1, Brain Funct Res Sect, Shenyang, Liaoning, Peoples R China
9.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Jingyu,Guo, Huiling,Sun, Dandan,et al. Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2019,11(9):5919-5931.
APA Yang, Jingyu.,Guo, Huiling.,Sun, Dandan.,Duan, Jia.,Rao, Xiaoping.,...&Wang, Fei.(2019).Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,11(9),5919-5931.
MLA Yang, Jingyu,et al."Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 11.9(2019):5919-5931.

入库方式： OAI收割

来源：武汉物理与数学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。