An ATP-Responsive Linear DNA Hydrogel
文献类型：期刊论文
| 作者 | Wang, F; Zhong, RB; Tang, Q; Wang, JB; Liu, HJ; Qu, XM; Wang, LH; Pei, H |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2018 |
| 期号 | 5页码:553-558 |
| 关键词 | ELECTROCHEMICAL BIOSENSOR SUPRAMOLECULAR HYDROGEL REVERSIBLE POLYMERS GOLD NANOPARTICLES BUILDING-BLOCKS BLOOD-SERUM APTAMER NANOSTRUCTURES ORIGAMI RELEASE |
| ISSN号 | 1000-3304 |
| DOI | 10.11777/j.issn1000-3304.2018.18070 |
| 文献子类 | 期刊论文 |
| 英文摘要 | A single-stranded DNA with adenosine triphosphate (ATP) aptamer sequence and a single-stranded DNA with cohesive end were designed for the formation of linear DNA hydrogel. First, a double-stranded DNA monomer was formed by the hybridization of sticky ends. Then this monomer self-assembled to form a long linear DNA polymer and further form a DNA hydrogel by physically cross-linking The formation of the hydrogel was characterized by rheological tests and the transition from the gel state to the solution state was observed by stress scanning. Using methylene blue (MB) as a marker, the responsive dynamics of the DNA hydrogel to ATP was characterized by UV absorption spectroscopy. Within 15 min after the addition of ATP, the absorbance of the DNA hydrogel at 664 nm rose rapidly and reached a plateau, indicating that the DNA hydrogel can respond quickly to ATP. Moreover, the absorbance of the DNA hydrogel at 664 nm has a good linear correlation with ATP concentration. For comparison, ATP, thymidine triphosphate (TTP), cytidine triphosphate (CTP) and guanosine triphosphate (GTP) were added to the DNA hydrogel, respectively. The UV absorption spectrum test showed that only the ATP-containing DNA hydrogel was depolymerized and MB was released, indicating that the DNA hydrogel has good stability and its response to ATP was specific. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30837]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, F,Zhong, RB,Tang, Q,et al. An ATP-Responsive Linear DNA Hydrogel[J]. ACTA POLYMERICA SINICA,2018(5):553-558. |
| APA | Wang, F.,Zhong, RB.,Tang, Q.,Wang, JB.,Liu, HJ.,...&Pei, H.(2018).An ATP-Responsive Linear DNA Hydrogel.ACTA POLYMERICA SINICA(5),553-558. |
| MLA | Wang, F,et al."An ATP-Responsive Linear DNA Hydrogel".ACTA POLYMERICA SINICA .5(2018):553-558. |
入库方式： OAI收割
来源：上海应用物理研究所
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