Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS
文献类型：期刊论文
| 作者 | Huang, LN; Zhang, XH; Ma, XH; Zhang, D; Li, DX; Peng, JL; Pan, XJ; Lu, JH; Wang, XZ; Liu, XY |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 65期号:-页码:96-107 |
| 关键词 | RESPIRATORY-DISTRESS-SYNDROME ACUTE LUNG INJURY NF-KAPPA-B SIGNALING PATHWAY MOUSE MODEL INFLAMMATION PROTECTS DAMAGE APOPTOSIS BARRIER |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2018.10.001 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis, a plant used in traditional Chinese medicine that exerts multiple pharmacological effects. In this study, pretreatment with BBR inhibited the increase in vascular endothelial permeability in mice with lipopolysaccharide (LPS)-induced ARDS. BBR pretreatment inhibited the shedding of syndecan-1 (SDC-1) and heparan sulfate (HS), which are important components of the endothelial glycocalyx that lessen endothelial glycocalyx damage. BBR further significantly inhibited increases in important endothelial glycocalyx damage factors, including reactive oxygen species (ROS), heparanase (HPA), and matrix metalloproteinase 9 (MMP9) in LPS-induced ARDS mice and in LPS-stimulated human umbilical vein endothelial cells. BBR pretreatment also decreased the production of pro-inflammatory cytokines TNF-alpha, IL-beta, IL-6, and inhibited NF-kappa B signaling pathway activation in LPS-induced ARDS. In addition, BBR promoted the recovery of SDC-1 and HS content in injured endothelial glycocalyx after LPS treatment and accelerated its restoration. This is the first report of BBR maintaining the integrity of endothelial glycocalyx. These results provide a new theoretical basis for the use of BBR in the treatment of ARDS and other diseases related to endothelial glycocalyx damage. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30860]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Binzhou Med Univ, Dept Cell Biol, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 3.Binzhou Med Univ, Dept Biotechnol, Yantai 264003, Shandong, Peoples R China 4.Binzhou Med Univ Binzhou, Affiliated Hosp, Dept Respirator Med, Yantai 256603, Shandong, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, LN,Zhang, XH,Ma, XH,et al. Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2018,65(-):96-107. |
| APA | Huang, LN.,Zhang, XH.,Ma, XH.,Zhang, D.,Li, DX.,...&Liu, XY.(2018).Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.INTERNATIONAL IMMUNOPHARMACOLOGY,65(-),96-107. |
| MLA | Huang, LN,et al."Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS".INTERNATIONAL IMMUNOPHARMACOLOGY 65.-(2018):96-107. |
入库方式： OAI收割
来源：上海应用物理研究所
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