Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells
文献类型：期刊论文
| 作者 | Wang, SQ; Ren, WZ; Wang, JH; Jiang, ZQ; Saeed, M; Zhang, LL; Li, AG; Wu, AG |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:8页码:2209-2218 |
| 关键词 | IMAGING CONTRAST AGENT PHOTODYNAMIC THERAPY BREAST-CANCER NANOPARTICLES NANOPLATFORM METASTASIS TIO2 NANOCOMPOSITES RESISTANCE TITANIA |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c8bm00454d |
| 文献子类 | 期刊论文 |
| 英文摘要 | At present, transmembrane glycoprotein CD133 highly expressed pancreatic cancer stem cells (PCSCs), with the features of chemotherapeutic/radiotherapeutic resistance and exclusive tumorigenic potential, are considered as the primary cause of metastasis and recurrence in pancreatic cancer, and therefore are an effective target in the disease treatment. Furthermore, with the launch of precision medicine, multifunctional nanoprobes have been applied as an efficient strategy for the magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) of pancreatic cancer. In this research, with the aim of achieving precise MRI-guided PTT in CD133 highly expressed PCSCs, novel bTiO(2)-Gd-CD133mAb nanoprobes were designed and successfully prepared by loading Gd-DOTA and CD133 monoclonal antibodies on black TiO2 nanoparticles. It was very interesting to find that the r(1) relaxivity value of the nanoprobes was 34.394 mM(-1) s(-1), about 7.5 times that of commercial Magnevist (4.5624 mM(-1) s(-1)), which indicates that the nanoprobes have good potential as MRI T-1 contrast agents with excellent performance. Herein, CD133 highly expressed PANC-1 cells were selected and verified as PCSCs model. In vitro experiments demonstrated that the nanoprobes exhibited active-targeting ability in PANC-1 cells, and consequently could specially enhance T-1-weighted MR imaging and 808 nm near-infrared (NIR)-triggered PTT efficiency in the PCSCs model. Our study not only provides a new strategy for the effective treatment of pancreatic cancer and its' stem cells, but also further broadens the application of black TiO2 in the field of cancer theranostics. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30866]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 3.Ningbo Univ, Affiliated Hosp, Med Sch, Dept Radiol, Ningbo 315020, Zhejiang, Peoples R China 4.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 5.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, SQ,Ren, WZ,Wang, JH,et al. Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells[J]. BIOMATERIALS SCIENCE,2018,6(8):2209-2218. |
| APA | Wang, SQ.,Ren, WZ.,Wang, JH.,Jiang, ZQ.,Saeed, M.,...&Wu, AG.(2018).Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells.BIOMATERIALS SCIENCE,6(8),2209-2218. |
| MLA | Wang, SQ,et al."Black TiO2-based nanoprobes for T-1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells".BIOMATERIALS SCIENCE 6.8(2018):2209-2218. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。