DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides
文献类型：期刊论文
| 作者 | Hu, QQ; Wang, S; Wang, LH; Gu, HZ; Fan, CH |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 7期号:20页码:- |
| 关键词 | ANTICANCER DRUG-DELIVERY SINGLE-STRANDED-DNA DOUBLE-CROSSOVER MOLECULES IMMUNOSTIMULATORY CPG DNA SPHERICAL NUCLEIC-ACIDS TARGETED CANCER-THERAPY SIRNA DELIVERY GOLD NANOPARTICLES RNA INTERFERENCE GENE-REGULATION |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201701153 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In the beginning of the 21st century, therapeutic oligonucleotides have shown great potential for the treatment of many life-threatening diseases. However, effective delivery of therapeutic oligonucleotides to the targeted location in vivo remains a major issue. As an emerging field, DNA nanotechnology is applied in many aspects including bioimaging, biosensing, and drug delivery. With sequence programming and optimization, a series of DNA nanostructures can be precisely engineered with defined size, shape, surface chemistry, and function. Simply with hybridization, therapeutic oligonucleotides including unmethylated cytosine-phosphate-guanine dinucleotide oligos, small interfering RNA (siRNA) or antisense RNA, single guide RNA of the regularly interspaced short palindromic repeat-Cas9 system, and aptamers, are successfully loaded on DNA nanostructures for delivery. In this progress report, the development history of DNA nanotechnology is first introduced, and then the mechanisms and means for cellular uptake of DNA nanostructures are discussed. Next, current approaches to deliver therapeutic oligonucleotides with DNA nanovehicles are summarized. In the end, the challenges and opportunities for DNA nanostructure-based systems for the delivery of therapeutic oligonucleotides are discussed. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30907]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Div Phys Biol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, QQ,Wang, S,Wang, LH,et al. DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(20):-. |
| APA | Hu, QQ,Wang, S,Wang, LH,Gu, HZ,&Fan, CH.(2018).DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.ADVANCED HEALTHCARE MATERIALS,7(20),-. |
| MLA | Hu, QQ,et al."DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides".ADVANCED HEALTHCARE MATERIALS 7.20(2018):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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