DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface
文献类型：期刊论文
| 作者 | Ding, HM; Li, J; Chen, N; Hu, XJ; Yang, XF; Guo, LJ; Li, Q; Zuo, XL; Wang, LH; Ma, YQ |
| 刊名 | ACS CENTRAL SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 4期号:10页码:1344-1351 |
| 关键词 | MAMMALIAN-CELLS DRUG-DELIVERY CANCER-CELLS TUMOR-CELLS PH CHANGES NANOPARTICLES ORIGAMI NANOCARRIERS MOLECULES PATHWAYS |
| ISSN号 | 2374-7943 |
| DOI | 10.1021/acscentsci.8b00383 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Cell entry of anionic nano-objects has been observed in various types of viruses and self-assembled DNA nanostructures. Nevertheless, the physical mechanism underlying the internalization of these anionic particles across the negatively charged cell membrane remains poorly understood. Here, we report the use of virus-mimicking designer DNA nanostructures with near-atomic resolution to program "like-charge attraction" at the interface of cytoplasmic membranes. Single-particle tracking shows that cellular internalization of tetrahedral DNA nanostructures (TDNs) depends primarily on the lipid-raft-mediated pathway, where caveolin plays a key role in providing the short-range attraction at the membrane interface. Both simulation and experimental data establish that TDNs approach the membrane primarily with their corners to minimize electrostatic repulsion, and that they induce uneven charge redistribution in the membrane under the short-distance confinement by caveolin. We expect that the nanoscale like-charge attraction mechanism provides new clues for viral entry and general rules for rational design of anionic carriers for therapeutics. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30908]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 2.Nanjing Univ, Collaborat Innovat Ctr Adv Microstruct, Natl Lab Solid State Microstruct, Nanjing 210093, Jiangsu, Peoples R China 3.Nanjing Univ, Collaborat Innovat Ctr Adv Microstruct, Dept Phys, Nanjing 210093, Jiangsu, Peoples R China 4.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China 5.Chinese Acad Sci, Div Phys Biol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 6.Chinese Acad Sci, Bioimaging Ctr, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 7.Soochow Univ, Ctr Soft Condensed Matter Phys & Interdisciplinar, Sch Phys Sci & Technol, Suzhou 215006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, HM,Li, J,Chen, N,et al. DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface[J]. ACS CENTRAL SCIENCE,2018,4(10):1344-1351. |
| APA | Ding, HM.,Li, J.,Chen, N.,Hu, XJ.,Yang, XF.,...&Fan, CH.(2018).DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface.ACS CENTRAL SCIENCE,4(10),1344-1351. |
| MLA | Ding, HM,et al."DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface".ACS CENTRAL SCIENCE 4.10(2018):1344-1351. |
入库方式： OAI收割
来源：上海应用物理研究所
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