Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production
文献类型：期刊论文
| 作者 | Liu, S; Cao, ST; Guo, JY; Luo, LQ; Zhou, Y; Lin, CL; Shi, JY; Fan, CH; Lv, M; Wang, LH |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:41页码:19603-19611 |
| 关键词 | ANTIBACTERIAL ACTIVITY NANOPARTICLE BACTERIA MECHANISMS RESISTANCE NANOMATERIALS COMPOSITES NANOSHEETS EVOLUTION TOXICITY |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c8nr04064h |
| 文献子类 | 期刊论文 |
| 英文摘要 | Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of an antibacterial graphene oxide-silver nanoparticles (GO-AgNPs) composite on Pseudomonas aeruginosa biofilm formation. We found that GO-AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 g mL(-1). Interestingly, the bacterial biomass significantly decreased, but extracellular polymeric substance (EPS) production remarkably increased in mature biofilms treated with GO-AgNPs of an appropriate concentration, suggesting that GO-AgNPs effectively modulate biofilm development and structure. Moreover, we established that GO-AgNPs caused bacterial death via both physical damage and oxidative stress, showing the synergic action of GO and AgNPs. These findings facilitate the use of graphene-based nanocomposites for greener antibiotic applications. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30959]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chengdu Univ Tradit Chinese Med, Sch Basic Med, Chengdu 611137, Sichuan, Peoples R China 2.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China 3.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Div Phys Biol, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Div Phys Biol, Shanghai 201800, Peoples R China 5.UCB Pharma, Slough SL1 3WE, Berks, England |
| 推荐引用方式 GB/T 7714 | Liu, S,Cao, ST,Guo, JY,et al. Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production[J]. NANOSCALE,2018,10(41):19603-19611. |
| APA | Liu, S.,Cao, ST.,Guo, JY.,Luo, LQ.,Zhou, Y.,...&Wang, LH.(2018).Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production.NANOSCALE,10(41),19603-19611. |
| MLA | Liu, S,et al."Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production".NANOSCALE 10.41(2018):19603-19611. |
入库方式： OAI收割
来源：上海应用物理研究所
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