Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery
文献类型：期刊论文
| 作者 | Zhang, YX; Ma, WJ; Zhu, Y; Shi, SR; Li, QS; Mao, CC; Zhao, D; Zhan, YX; Shi, JY; Li, W |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 18期号:9页码:5652-5659 |
| 关键词 | DRUG-DELIVERY ESCHERICHIA-COLI SELECTIVE RECOGNITION NEGATIVE BACTERIA STEM-CELLS PATHWAY NANOPARTICLES FTSZ DIFFERENTIATION NANOTECHNOLOGY |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.8b02166 |
| 文献子类 | 期刊论文 |
| 英文摘要 | One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing vectors, such as cell penetrating peptides, are inefficient and nontargeting, and accordingly are not ideal carriers. A noncytotoxic tetrahedral DNA nanostructure (TDN) with a controllable conformation has been developed as a delivery vehicle for antisense oligonucleotides. In this study, antisense peptide nucleic acids (asPNAs) targeting a specific gene (ftsZ) were efficiently transported into methicillin-resistant Staphylococcus aureus cells by TDNs, and the expression of ftsZ was successfully inhibited in an asPNA-concentration-dependent manner. The delivery system specifically targeted the intended gene. This novel delivery system provides a better platform for future applications of antisense antibacterial therapeutics and provides a basis for the development of a new type of antibacterial drug for multi-drug-resistant bacterial infections. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/30997]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China 3.Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, YX,Ma, WJ,Zhu, Y,et al. Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery[J]. NANO LETTERS,2018,18(9):5652-5659. |
| APA | Zhang, YX.,Ma, WJ.,Zhu, Y.,Shi, SR.,Li, QS.,...&Lin, YF.(2018).Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery.NANO LETTERS,18(9),5652-5659. |
| MLA | Zhang, YX,et al."Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery".NANO LETTERS 18.9(2018):5652-5659. |
入库方式： OAI收割
来源：上海应用物理研究所
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