Material distributions and functional structures in probiotic microcapsules
文献类型：期刊论文
| 作者 | Wu, L; Qin, W; He, YZ; Zhu, WF; Ren, XH; York, P; Xiao, TQ; Yin, XZ; Zhang, JW |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2018 |
| 卷号 | 122期号:-页码:1-8 |
| 关键词 | X-RAY MICROTOMOGRAPHY SIMULATED GASTROINTESTINAL CONDITIONS OSMOTIC PUMP TABLETS CONTROLLED-RELEASE VIABILITY PREVENTION RADIATION BIFIDOBACTERIA ENCAPSULATION MICROSPHERES |
| ISSN号 | 0928-0987 |
| DOI | 10.1016/j.ejps.2018.06.013 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Smart microstructure design of dosage forms such as microcapsules that protect the microorganism, can improve probiotics survival from gastric pH challenges and prolong their shelf life. In this study, synchrotron radiation Xray microcomputed tomography (SR-mu CT) was applied to quantitatively reveal the material distributions and functional structures of bifidobacterium and lactobacillus microcapsules. The shell layer, middle protective layer, and the microorganisms as particles in the center layer were extracted and visualized. All the microorganisms were encapsulated by the shell completely, which prevents them from being destroyed by external environments. However, the non-uniform thickness of the shell and typical defects in the microcapsules were observed. The quantitative analysis and characterization of internal microstructures provide evidence of the need for further improvement in formulations and processing technologies for the structured system to deliver living microorganisms. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31022]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 2.Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China 3.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England 4.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China 5.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, L,Qin, W,He, YZ,et al. Material distributions and functional structures in probiotic microcapsules[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2018,122(-):1-8. |
| APA | Wu, L.,Qin, W.,He, YZ.,Zhu, WF.,Ren, XH.,...&Zhang, JW.(2018).Material distributions and functional structures in probiotic microcapsules.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,122(-),1-8. |
| MLA | Wu, L,et al."Material distributions and functional structures in probiotic microcapsules".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 122.-(2018):1-8. |
入库方式： OAI收割
来源：上海应用物理研究所
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