Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
文献类型：期刊论文
| 作者 | Cui, ZF; Zhang, Y; Xia, K; Yan, QL; Kong, HT; Zhang, JC; Zuo, XL; Shi, JY; Wang, LH; Zhu, Y |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:- |
| 关键词 | ACUTE PROMYELOCYTIC LEUKEMIA CELL-DEATH CANCER TRIOXIDE APOPTOSIS HYDROXYCHLOROQUINE CHLOROQUINE CARCINOMA DRUGS MODEL |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-06749-2 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Arsenic trioxide (ATO) is a successful chemotherapeutic drug for blood cancers via selective induction of apoptosis; however its efficacy in solid tumors is limited. Here we repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to allosterically improve the therapeutic efficacy of ATO-based treatment in solid tumors. We find that NDs and ATO are physically separate and functionally target different cellular pathways (autophagy vs. apoptosis); whereas their metabolic coupling in human liver carcinoma cells remarkably enhances programmed cell death. Combination therapy in liver tumor mice model results in similar to 91% carcinoma decrease as compared with similar to 28% without NDs. Treated mice show 100% survival rate in 150 days with greatly reduced advanced liver carcinoma-associated symptoms, and similar to 80% of post-therapy mice survive for over 20 weeks. Our work presents a novel strategy to harness the power of nanoparticles to broaden the scope of ATO-based therapy and more generally to fight solid tumors. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31039]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Renji Hosp, Inst Mol Med,Sch Med, Shanghai 200240, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China 3.Univ Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Chinese Acad Sci,Div Phys Biol & Bioimaging Ctr, Shanghai 201800, Peoples R China 4.Univ Oxford, Kellogg Coll, Banbury Rd, Oxford OX2 6PN, England |
| 推荐引用方式 GB/T 7714 | Cui, ZF,Zhang, Y,Xia, K,et al. Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors[J]. NATURE COMMUNICATIONS,2018,9(-):-. |
| APA | Cui, ZF.,Zhang, Y.,Xia, K.,Yan, QL.,Kong, HT.,...&Fan, CH.(2018).Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors.NATURE COMMUNICATIONS,9(-),-. |
| MLA | Cui, ZF,et al."Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors".NATURE COMMUNICATIONS 9.-(2018):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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