Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors
文献类型：期刊论文
| 作者 | Chen, N; Han, YP; Luo, Y; Zhou, YF; Hu, XJ; Yu, Y; Xie, XD; Yin, M; Sun, JL; Zhong, WY |
| 刊名 | MATERIALS HORIZONS
 |
| 出版日期 | 2018 |
| 卷号 | 5期号:6页码:1204-1210 |
| 关键词 | HYPOXIA-INDUCED AUTOPHAGY DOUBLE-EDGED-SWORD FLUORESCENT NANODIAMONDS BREAST-CANCER QUANTUM DOTS IN-VIVO NANOPARTICLES INDUCTION APOPTOSIS THERAPY |
| ISSN号 | 2051-6347 |
| DOI | 10.1039/c8mh00993g |
| 文献子类 | 期刊论文 |
| 英文摘要 | The tumor microenvironment (TME) plays a key role in tumor progression and has been actively explored as a promising target for cancer therapy. One key challenge in TME-based therapy lies in the presence of high levels of autophagy under oxygen-deprived conditions (referred to as hypoxia), which is an evolution-based adaptive strategy of cancer cells to facilitate tumor growth and metastasis. Here, we utilize a type of biocompatible nanoparticle, nanodiamonds (NDs), to block autophagic flux in cultured cells and xenograft tumors. Whereas ND treatment has little effect on the cell viability under normal oxygen levels (referred to as normoxia), it selectively induces programmed cell death in hypoxic cancer cells, thus showing specificity for in vivo tumors. Unlike clinically used autophagy inhibitors that demonstrate general toxicity and activate HIF signaling, we find that NDs selectively inhibit autophagic degradation with minimal impairment of lysosomal functions and do not affect HIF activity. Significantly, intravenous injection of NDs acts synergistically with Sorafenib, an anti-angiogenic drug used clinically for cancer therapy, to inhibit the growth of hepatocellular carcinoma in mice. This distinct mechanism of NDs opens a new door for targeted anti-angiogenic therapy of solid tumors. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31040]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chengdu Med Coll, Dept Anat & Histol & Embryol, Dev & Regenerat Key Lab Sichuan Prov, Chengdu 610500, Sichuan, Peoples R China 2.Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.Sichuan Univ, Sch Life Sci, Chengdu 610064, Sichuan, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Shanghai 200025, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, N,Han, YP,Luo, Y,et al. Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors[J]. MATERIALS HORIZONS,2018,5(6):1204-1210. |
| APA | Chen, N.,Han, YP.,Luo, Y.,Zhou, YF.,Hu, XJ.,...&Fan, CH.(2018).Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors.MATERIALS HORIZONS,5(6),1204-1210. |
| MLA | Chen, N,et al."Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors".MATERIALS HORIZONS 5.6(2018):1204-1210. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。