Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA
文献类型：期刊论文
| 作者 | Lai, W; Ren, L; Tang, Q; Qu, XM; Li, J; Wang, LH; Li, L; Fan, CH; Pei, H |
| 刊名 | ACS NANO
 |
| 出版日期 | 2018 |
| 卷号 | 12期号:7页码:7093-7099 |
| 关键词 | STRAND-DISPLACEMENT-REACTIONS NUCLEIC-ACID NANOSTRUCTURES RATIONAL DESIGN TOEHOLD HYBRIDIZATION KINETICS NANOTECHNOLOGY COMPUTATION CASCADES CIRCUIT |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b02864 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The programmable regulation of chemical reaction networks (CRNs) represents a major challenge toward the development of complex molecular devices performing sophisticated motions and functions. Nevertheless, regulation of artificial CRNs is generally energy and time-intensive as compared to natural regulation. Inspired by allosteric regulation in biological CRNs, we herein develop an intramolecular conformational motion strategy (InCMS) for programmable regulation of DNA CRNs. We design a DNA switch as the regulatory element to program the distance between the toehold and branch migration domain. The presence of multiple conformational transitions leads to wide-range kinetic regulation spanning over 4 orders of magnitude. Furthermore, the process of energy-cost-free strand exchange accompanied by conformational change discriminates single base mismatches. Our strategy thus provides a simple yet effective approach for dynamic programming of complex CRNs. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31076]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China 2.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, W,Ren, L,Tang, Q,et al. Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA[J]. ACS NANO,2018,12(7):7093-7099. |
| APA | Lai, W.,Ren, L.,Tang, Q.,Qu, XM.,Li, J.,...&Pei, H.(2018).Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA.ACS NANO,12(7),7093-7099. |
| MLA | Lai, W,et al."Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA".ACS NANO 12.7(2018):7093-7099. |
入库方式： OAI收割
来源：上海应用物理研究所
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