Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level
文献类型：期刊论文
| 作者 | Wang, XM; Ji, GX; Shi, C; Juan, DW; Chen, LH; Gui, DX; Wan, JM; Silver, MA; Wang, JQ; Wang, S |
| 刊名 | DALTON TRANSACTIONS
 |
| 出版日期 | 2018 |
| 卷号 | 47期号:26页码:8764-8770 |
| 关键词 | IRON-CHELATION THERAPY HYDROXYPYRIDINONATE LIGANDS DECORPORATION AGENTS DRUG DEFERIPRONE ORAL DEFERIPRONE TOXICITY URANIUM MICE CATECHOLATE MECHANISM |
| ISSN号 | 1477-9226 |
| DOI | 10.1039/c8dt01738g |
| 文献子类 | 期刊论文 |
| 英文摘要 | Deferiprone (3-hydroxy-1,2-dimethyl-4(1H)-pyridone, DFP), which is a drug clinically used for removing heavy metals in vivo, was explored for its removal efficiency towards uranium. The reaction of uranyl nitrate hexahydrate with DFP at room temperature yielded the compound [(UO2)(H2O)(C7NO2H8)(2)]4H(2)O (1), which crystallizes from a mixed solution of methanol and water (pH = 7.0). X-ray diffraction shows that the stable complexation of uranyl occurs from the coordination of two bidentate DFP ligands perpendicular to the O?U?O unit with a fifth coordinating oxygen atom coming from one water molecule, resulting in a pentagonal bipyramidal geometry. The formation constants of uranyl and DFP complexes were measured and the species distribution diagram illustrates that UO2L2 (94.6%) is the dominant uranyl-DFP complex in 0.1 M KCl solution at physiological pH = 7.4. The results from both crystallographic and potentiometric studies imply that the metal:ligand ratio is 1:2. The effectiveness of using DFP to remove uranium was examined at the cellular level, and the results suggest that it can significantly reduce the cellular uptake and increase the cellular release of U(vi) in renal proximal tubular epithelial cells (NRK-52E). |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31122]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Jiangsu, Peoples R China 2.Xian Res Inst Hitech, Xian, Shaanxi, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Shanghai 201800, Peoples R China 4.Univ Chinese Acad Sci, Beijing 210049, Peoples R China 5.Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, XM,Ji, GX,Shi, C,et al. Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level[J]. DALTON TRANSACTIONS,2018,47(26):8764-8770. |
| APA | Wang, XM.,Ji, GX.,Shi, C.,Juan, DW.,Chen, LH.,...&Wang, S.(2018).Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level.DALTON TRANSACTIONS,47(26),8764-8770. |
| MLA | Wang, XM,et al."Structural and thermodynamic stability of uranyl-deferiprone complexes and the removal efficacy of U(vi) at the cellular level".DALTON TRANSACTIONS 47.26(2018):8764-8770. |
入库方式： OAI收割
来源：上海应用物理研究所
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