Two-Dimensional MXene (Ti3C2)-Integrated Cellulose Hydrogels: Toward Smart Three-Dimensional Network Nanoplatforms Exhibiting Light-Induced Swelling and Bimodal Photothermal/Chemotherapy Anticancer Activity
文献类型：期刊论文
| 作者 | Xing, CY; Chen, SY; Liang, X; Liu, Q; Qu, MM; Zou, QS; Li, JH; Tan, H; Liu, LP; Fan, DY |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:33页码:27631-27643 |
| 关键词 | PHOSPHORUS QUANTUM DOTS PHOTOTHERMAL THERAPY GRAPHENE OXIDE COMPOSITE NANOSHEETS TUMOR CONVERSION DELIVERY NITRIDE TI3C2 |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b08314 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Two-dimensional (2D) MXenes have recently been shown to be promising for applications in anticancer photothermal therapy (PTT), owing to their outstanding photothermal performance. However, as with the other inorganic 2D nanomaterials, the MXene-based nanoplatforms lack the appropriate biocompatibility and stability in physiological conditions, targeting capability, and controlled release of drug, for cancer therapy. Fabricating a smart MXene-based nanoplatform for the treatment of cancer therefore remains a challenge. In this work, composite hydrogels based on cellulose and Ti3C2 MXene, were synthesized for the first time. We have shown that the cellulose/MXene composite hydrogels possess rapid response near-infrared-stimulated characteristics, which present as a continuous dynamic process in water. As a result, when loaded with the anticancer drug doxorubicin hydrochloride (DOX), the cellulose/MXene hydrogels are capable of significantly accelerating the DOX release. This behavior is attributed to the expansion of the pores within the three-dimensional cellulose-based networks, triggered by illumination with an 808 nm light. Capitalizing on their excellent photothermal performance and controlled, sustained release of DOX, the cellulose/MXene hydrogels are utilized as a multifunctional nanoplatform for tumor treatment by intratumoral injection. The results showed that the combination of PTT and prolonged adjuvant chemotherapy delivered using this nanoplatform was highly efficient for instant tumor destruction and for suppressing tumor relapse, demonstrating the potential of the nanoplatform for application in cancer therapy. Our work not only opens the door for the fabrication of smart MXene-based nanocomposites, along with their promising application against cancer, but also paves the way for the development of other inorganic 2D composites for applications in biomedicine. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31157]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China 2.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Key Lab Neurosurg, Shenzhen 518035, Peoples R China 3.Shenzhen Univ, Shenzhen Engn Lab Phosphorene & Optoelect, Int Collaborat Lab Mat Optoelect Sci & Technol 2D, Minist Educ,Coll Optoelect Engn, Shenzhen 518060, Peoples R China 4.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Hepatobiliary & Pancreat Surg, Shenzhen 518060, Guangdong, Peoples R China 5.Shenzhen Univ, Coll Mat Sci & Engn, Shenzhen 518060, Peoples R China 6.Beijing 302 Hosp, Res Ctr Clin & Translat Med, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, CY,Chen, SY,Liang, X,et al. Two-Dimensional MXene (Ti3C2)-Integrated Cellulose Hydrogels: Toward Smart Three-Dimensional Network Nanoplatforms Exhibiting Light-Induced Swelling and Bimodal Photothermal/Chemotherapy Anticancer Activity[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(33):27631-27643. |
| APA | Xing, CY.,Chen, SY.,Liang, X.,Liu, Q.,Qu, MM.,...&Zhang, H.(2018).Two-Dimensional MXene (Ti3C2)-Integrated Cellulose Hydrogels: Toward Smart Three-Dimensional Network Nanoplatforms Exhibiting Light-Induced Swelling and Bimodal Photothermal/Chemotherapy Anticancer Activity.ACS APPLIED MATERIALS & INTERFACES,10(33),27631-27643. |
| MLA | Xing, CY,et al."Two-Dimensional MXene (Ti3C2)-Integrated Cellulose Hydrogels: Toward Smart Three-Dimensional Network Nanoplatforms Exhibiting Light-Induced Swelling and Bimodal Photothermal/Chemotherapy Anticancer Activity".ACS APPLIED MATERIALS & INTERFACES 10.33(2018):27631-27643. |
入库方式： OAI收割
来源：上海应用物理研究所
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