ZD2-Engineered Gold Nanostar@Metal-Organic Framework Nanoprobes for T-1-Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple-Negative Breast Cancer
文献类型：期刊论文
| 作者 | Zhang, LY; Liu, C; Gao, Y; Li, ZH; Xing, J; Ren, WZ; Zhang, LL; Li, AG; Lu, GM; Wu, AG |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2018 |
| 卷号 | 7期号:24页码:- |
| ISSN号 | 2192-2640 |
| 关键词 | NANOPARTICLES NANOSTRUCTURES NANORODS CLUSTERS |
| DOI | 10.1002/adhm.201801144 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Compared with other subtypes of breast cancer, triple-negative breast cancer (TNBC) is seriously threatening to human life. Therefore, it is a matter of urgency to develop multifunctional nanoprobes for visualized theranostics of TNBC, achieving specific targeting toward only TNBC, but not other subtypes. Nanoscale metal-organic frameworks (MOFs) show important potential in visualized theranostics of tumors, but it is critical to synthesize well-defined core-shell MOF-based nanocomposites by encapsulating a single nanoparticle within MOF. In this study, a TNBC-targeted peptide (ZD2)-engineered, and a single gold nanostar (AuNS) coated within MIL-101-NH2(Fe) by coating MOF with four cycles, obtain well-defined core-shell AuNS@MOF-ZD2 nanocomposites, which are expected to achieve T-1-weighted magnetic resonance imaging and photothermal therapy (PTT) specifically targeting toward TNBC. The prepared AuNS@MOF-ZD2 nanocomposites possess good biocompatibility, efficient T-1-weighted magnetic resonance (MR) relaxivity and stable photothermal conversion ability with an efficiency of 40.5%. The in vitro and in vivo characterizations prove their performances of T-1-weighted MR and PTT with a low power density of 808 nm laser, achieving excellent theranostic efficacy in TNBC. Importantly, it is demonstrated that the prepared AuNS@MOF-ZD2 nanoprobes can specifically target TNBC cells (MDA-MB-231), but not other subtypes of breast cancer cells (MDA-MB-435, MDA-MB-468, and MCF-7), indicating their promising application in visualized theranostics of breast cancers with molecular classification. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31176]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210002, Jiangsu, Peoples R China 2.Hebei Univ, Coll Chem & & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China 3.Hebei Univ, Coll Chem & & Environm Sci, Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China 4.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Zhejiang, Peoples R China 5.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Zhejiang, Peoples R China 6.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, Ningbo 315201, Zhejiang, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, LY,Liu, C,Gao, Y,et al. ZD2-Engineered Gold Nanostar@Metal-Organic Framework Nanoprobes for T-1-Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple-Negative Breast Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(24):-. |
| APA | Zhang, LY.,Liu, C.,Gao, Y.,Li, ZH.,Xing, J.,...&Zeng, LY.(2018).ZD2-Engineered Gold Nanostar@Metal-Organic Framework Nanoprobes for T-1-Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple-Negative Breast Cancer.ADVANCED HEALTHCARE MATERIALS,7(24),-. |
| MLA | Zhang, LY,et al."ZD2-Engineered Gold Nanostar@Metal-Organic Framework Nanoprobes for T-1-Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple-Negative Breast Cancer".ADVANCED HEALTHCARE MATERIALS 7.24(2018):-. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。