Enhanced oxidation stability of highly cross-linked ultrahigh molecular weight polyethylene by tea polyphenols for total joint implants
文献类型：期刊论文
| 作者 | Ren, Y; Zhang, ZY; Lan, RT; Xu, L; Gao, Y; Zhao, BS; Xu, JZ; Gul, RM; Li, ZM |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 94期号:-页码:211—219 |
| 关键词 | IN-VITRO WEAR VITAMIN-E ALPHA-TOCOPHEROL MECHANICAL-PROPERTIES UHMWPE IRRADIATION RESISTANCE LINKING RAMAN STERILIZATION |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2018.09.036 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Despite being currently state-of-the-art to prevent the oxidation of irradiated ultrahigh molecular weight polyethylene (UHMWPE) bearings, vitamin E (VE) poses concerns in the loss of cross-linking efficiency and is limited to be used at very low concentrations. It thus emphasizes the urgent demand for more efficient stabilizers. In this study, oxidation stability of highly cross-linked UHMWPE was demonstrated to be enhanced by tea polyphenols, such as lipid-soluble tea polyphenols (lsPPT), epigallocatechin gallate (EGCG), and lipid-soluble epigallocatechin gallate (IsEGCG). These antioxidants were blended with UHMWPE granules and consolidated by compression molding prior to E-beam irradiation. The presence of tea polyphenols substantially prolonged oxidation induction time of the irradiated UHMWPE before and after accelerated aging. Especially, lsEGCG was significantly superior to VE in terms of stabilizing capacity. Explained by the hydrogen donation mechanism, tea polyphenols with multiple phenolic hydroxyls could scavenge more radiation-induced free radicals than VE with only one phenolic hydroxyl, which was verified by the electron spin resonance spectra. Intriguingly, tea polyphenols showed less inhibitive effect on the cross-link density of irradiated UHMWPE than VE. Besides, there is no significant difference in crystallinity, mechanical performance as well as in vitro biocompatibility between the irradiated UHMWPE stabilized by tea polyphenols and VE. These findings highlight tea polyphenols, especially IsEGCG, are promising alternatives to extend the life span of UHMWPE implants. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31604]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201899, Peoples R China; 2.Sichuan Univ, State Key Lab Polymer Mat Engn, Coll Polymer Sci & Engn, Chengdu 610065, Sichuan, Peoples R China; 3.Univ Engn & Technol, Dept Mech Engn, Peshawar 25120, Pakistan 4.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Anesthesiol, Guangzhou 510623, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ren, Y,Zhang, ZY,Lan, RT,et al. Enhanced oxidation stability of highly cross-linked ultrahigh molecular weight polyethylene by tea polyphenols for total joint implants[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,94(-):211—219. |
| APA | Ren, Y.,Zhang, ZY.,Lan, RT.,Xu, L.,Gao, Y.,...&Li, ZM.(2019).Enhanced oxidation stability of highly cross-linked ultrahigh molecular weight polyethylene by tea polyphenols for total joint implants.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,94(-),211—219. |
| MLA | Ren, Y,et al."Enhanced oxidation stability of highly cross-linked ultrahigh molecular weight polyethylene by tea polyphenols for total joint implants".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 94.-(2019):211—219. |
入库方式： OAI收割
来源：上海应用物理研究所
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