Framework nucleic acids as programmable carrier for transdermal drug delivery
文献类型：期刊论文
| 作者 | Wiraja, C; Zhu, Y; Lio, DCS; Yeo, DC; Xie, M; Fang, WN; Li, Q; Zheng, MJ; Van Steensel, M; Wang, LH |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:— |
| 关键词 | DNA ORIGAMI NANOSTRUCTURES SKIN PENETRATION NANOPARTICLES DOXORUBICIN DERMATITIS LIPOSOMES SIZE |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-09029-9 |
| 文献子类 | 期刊论文 |
| 英文摘要 | DNA nanostructures are promising drug carriers with their intrinsic biocompatibility, uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at targeted sites following systemic administration, hindering their biomedical applications. Here we demonstrate transdermal delivery of framework nucleic acids (FNAs) through topical applications. By designing FNAs with distinct shapes and sizes, we interrogate their penetration on mice and human skin explant. Skin histology reveals size-dependent penetration, with FNAs <= 75 nm effectively reaching dermis layer. 17 nm-tetrahedral FNAs show greatest penetration to 350 mu m from skin periphery. Importantly, structural integrity is maintained during the skin penetration. Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates >= 2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31643]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China; 2.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore; 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China; 4.Natl Dent Ctr Singapore, 5 Second Hosp Ave, Singapore 168938, Singapore 5.Nanyang Technol Univ, NTU Northwestern Inst Nanomed, 50 Nanyang Ave, Singapore 639798, Singapore; 6.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China; 8.Nanyang Technol Univ, Sch Chem & Biomed Engn, 62 Nanyang Dr, Singapore 637459, Singapore; 9.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wiraja, C,Zhu, Y,Lio, DCS,et al. Framework nucleic acids as programmable carrier for transdermal drug delivery[J]. NATURE COMMUNICATIONS,2019,10(-):—. |
| APA | Wiraja, C.,Zhu, Y.,Lio, DCS.,Yeo, DC.,Xie, M.,...&Xu, CJ.(2019).Framework nucleic acids as programmable carrier for transdermal drug delivery.NATURE COMMUNICATIONS,10(-),—. |
| MLA | Wiraja, C,et al."Framework nucleic acids as programmable carrier for transdermal drug delivery".NATURE COMMUNICATIONS 10.-(2019):—. |
入库方式： OAI收割
来源：上海应用物理研究所
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