Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors
文献类型：期刊论文
| 作者 | Ye, DK; Li, L; Li, ZH; Zhang, YY; Li, M; Shi, JY; Wang, LH; Fan, CH; Yu, JH; Zuo, XL |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2019 |
| 卷号 | 19期号:1页码:369—374 |
| 关键词 | BIOSENSING INTERFACE MICROFLUIDICS DIAGNOSTICS OPERATION PROTEINS DISEASES PLATFORM DEVICES STORAGE |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.8b04051 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Molecular transport controls the efficiency of complex biological network systems such as cellular signaling system and cascade biomedical reaction. However, device fabrication for molecular sensing is often restricted by a low transport efficiency and complicated processing. Here, we report a molecular threading-dependent transport system using three-dimensional (3D) paper origami enabling the directional transport of biomolecules. We demonstrate that framework nucleic acid based interface engineering allows orthogonal molecular recognition and enzymatic reaction with programmed order on site. We thus develop a single-step electrochemical DNA sensor for quantitative analysis with 1 picomolar sensitivity within 60 min. Our sensor can discriminate a mismatched target at the level of a single base mismatch. Our study shows a great potential toward the development of a biomimetic molecular transport system for point-of-care and precision diagnosis. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31713]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; 4.Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interficial Phys & Technol, Bioimaging Ctr,SSRF, Shanghai 201800, Peoples R China; 6.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ye, DK,Li, L,Li, ZH,et al. Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors[J]. NANO LETTERS,2019,19(1):369—374. |
| APA | Ye, DK.,Li, L.,Li, ZH.,Zhang, YY.,Li, M.,...&Zuo, XL.(2019).Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors.NANO LETTERS,19(1),369—374. |
| MLA | Ye, DK,et al."Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors".NANO LETTERS 19.1(2019):369—374. |
入库方式： OAI收割
来源：上海应用物理研究所
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