Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection
文献类型：期刊论文
| 作者 | Guo, BD; Wang, HN; Yang, B; Jiang, WJ; Jing, MF; Li, HY; Xia, YA; Xu, YP; Hu, QL; Wang, FF |
| 刊名 | MOLECULAR PLANT
 |
| 出版日期 | 2019 |
| 卷号 | 12期号:4页码:552—564 |
| 关键词 | DISEASE RESISTANCE PLASMA-MEMBRANE PATHOGEN IMMUNITY SUSCEPTIBILITY TARGETS PLANTS TRANSFORMATION SUPPRESSION EXPRESSION |
| ISSN号 | 1674-2052 |
| DOI | 10.1016/j.molp.2019.01.017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six alpha helices and two WY motifs. The first two alpha helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31758]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Minist Educ, Key Lab Integrated Management Crop Dis & Pests, Nanjing 210095, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Appl Phys, 239 Zhangheng Rd, Shanghai 201204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Ctr Plant Stress Biol, Natl Key Lab Plant Mol Genet,CAS Ctr Excellence M, Shanghai 201204, Peoples R China; 4.Nanjing Agr Univ, Dept Plant Pathol, Nanjing 210095, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Guo, BD,Wang, HN,Yang, B,et al. Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection[J]. MOLECULAR PLANT,2019,12(4):552—564. |
| APA | Guo, BD.,Wang, HN.,Yang, B.,Jiang, WJ.,Jing, MF.,...&Wang, YC.(2019).Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.MOLECULAR PLANT,12(4),552—564. |
| MLA | Guo, BD,et al."Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection".MOLECULAR PLANT 12.4(2019):552—564. |
入库方式： OAI收割
来源：上海应用物理研究所
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