Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution
文献类型：期刊论文
| 作者 | Song, DK; Meng, JC; Cheng, J; Fan, Z; Chen, PY; Ruan, HF; Tu, ZY; Kang, N; Li, N; Xu, Y |
| 刊名 | NATURE MICROBIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 4期号:1页码:97—+ |
| ISSN号 | 2058-5276 |
| 关键词 | N-3-OXODODECANOYL HOMOSERINE LACTONE NF-KAPPA-B PLASMA-MEMBRANE MODEL MEMBRANES TNF-ALPHA RAFTS MOLECULES DIFFUSION ACTIVATION RECEPTORS |
| DOI | 10.1038/s41564-018-0290-8 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Bacterial quorum-sensing autoinducers are small chemicals released to control microbial community behaviours. N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas aeruginosa Lasl-LasR circuitry, triggers significant cell death in lymphocytes. We found that this molecule is incorporated into the mammalian plasma membrane and induces dissolution of eukaryotic lipid domains. This event expels tumour necrosis factor receptor 1 into the disordered lipid phase for its spontaneous trimerization without its ligand and drives caspase 3-caspase 8-mediated apoptosis. In vivo, P. aeruginosa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own better survival; conversely, blockage of caspases strongly reduces the severity of the infection. This work reveals an unknown communication method between microorganisms and the mammalian host and suggests interventions of bacterial infections by intercepting quorum-sensing signalling. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31780]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Univ Calgary, Snyder Inst, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada; 2.Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat, MOE, Beijing, Peoples R China; 3.Nankai Univ, Coll Life Sci, Dept Microbiol,Minist Educ, State Key Lab Med Chem Biol,Key Lab Mol Microbiol, Tianjin, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China; 5.Tsinghua Univ, Ctr Life Sci, Inst Immunol, Dept Basic Med Sci, Beijing, Peoples R China; 6.Univ Calgary, Snyder Inst, Dept Anat, Calgary, AB, Canada 7.Nanjing Agr Univ, Dept Microbiol, Nanjing, Jiangsu, Peoples R China; 8.Univ Calgary, Snyder Inst, Dept Cell Biol, Calgary, AB, Canada; 9.Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA; 10.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Song, DK,Meng, JC,Cheng, J,et al. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution[J]. NATURE MICROBIOLOGY,2019,4(1):97—+. |
| APA | Song, DK.,Meng, JC.,Cheng, J.,Fan, Z.,Chen, PY.,...&Shi, Y.(2019).Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution.NATURE MICROBIOLOGY,4(1),97—+. |
| MLA | Song, DK,et al."Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution".NATURE MICROBIOLOGY 4.1(2019):97—+. |
入库方式： OAI收割
来源：上海应用物理研究所
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