Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model
文献类型：期刊论文
| 作者 | Dai, LY; Huang, RH; Zhou, Y; Gu, HL; Wang, YB; Yang, CCJ; Xu, X; Ye, M; Bai, YR; Liu, YL |
| 刊名 | DOSE-RESPONSE
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:1页码:— |
| 关键词 | RADIOTHERAPY SBRT SOY ISOFLAVONES LUNG-CANCER RADIOSURGERY TISSUE |
| ISSN号 | 1559-3258 |
| DOI | 10.1177/1559325819828623 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The study aimed to develop a novel dose conversion platform by improving linear-quadratic (LQ) model to more accurately describe radiation response for high fraction/acute doses. This article modified the LQ model via piecewise fitting the biological dose curve using different fractionated dose and optimizing the consistency between mathematical model and experimental data to gain a more reasonable transform. That mathematical development of the LQ model further amended certain deviations of various cell curves with high doses and implied the rationality of the present model at low dose range. The modified biologically effective dose model that solved the dilemma of inaccurate LQ model had been used in comparing between hypofractionated and conventional fractioned dose. It has been verified that the calculated values are similar in the treatment of same efficacy, no matter what alpha/beta is, and provided a more rational explanation for significant differences among various hypofractionations. The equivalent uniform dose based on the subsection function could represent arbitrary inhomogeneous dose distributions including high-dose fractions, providing a foundation for the implementation of detailed evaluation of different cell dose effects. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31797]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Soochow Univ, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect, Suzhou, Jiangsu, Peoples R China; 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Radiat Oncol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Radiat Oncol, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Shanghai, Peoples R China; 6.Barnabas Hlth, Monmouth Med Ctr, Dept Radiat Oncol, Long Branch, NJ USA; 7.Soochow Univ, Affiliated Hosp 2, Dept Nucl Accid Med Emergency, Suzhou, Jiangsu, Peoples R China; 8.Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou, Jiangsu, Peoples R China; 9.Fujian Med Univ, Dept Radiat Oncol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China; 10.Fujian Med Univ, Coll Med Technol & Engn, Fuzhou, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, LY,Huang, RH,Zhou, Y,et al. Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model[J]. DOSE-RESPONSE,2019,17(1):—. |
| APA | Dai, LY.,Huang, RH.,Zhou, Y.,Gu, HL.,Wang, YB.,...&Ma, XM.(2019).Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model.DOSE-RESPONSE,17(1),—. |
| MLA | Dai, LY,et al."Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model".DOSE-RESPONSE 17.1(2019):—. |
入库方式： OAI收割
来源：上海应用物理研究所
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