Starvation effect on the morphology of microvilli in HeLa cells
文献类型：期刊论文
| 作者 | Liu, L; Wang, KZ; Liu, JY; Wei, YH; Liu, WJ; Zhang, P; Hu, J; Li, B |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 514期号:4页码:1238—1243 |
| 关键词 | ATOMIC-FORCE MICROSCOPY SURFACE VOLUME |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2019.05.073 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Microvilli are membrane protrusions enabling the increase of the cell surface area by over hundreds fold, thereby enhancing nutrition absorption. However, the correlation between the morphology of the microvilli and absorption capability of cells remains elusive. Herein, by combining atomic force microscopy with fluorescence microscopy, we explored the effects of starvation on the morphology of microvilli in HeLa cells at the single cell level. We found that there is an increasing signal of dextran absorption after starvation, and importantly, we observed a significant increase in the number of single microvillus and the lamella-shaped microvilli on the surface of HeLa cells. In addition, we also found reversible changes in the morphology of microvilli under starvation stress and after relief from starvation. These phenomena indicate that the morphology of the microvilli plays a crucial role in absorption capacity of HeLa cells. Our finding provides direct evidence for comprehensive understanding the function of microvilli. (C) 2019 The Authors. Published by Elsevier Inc. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31826]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol & Bioimaging Ctr,Shanghai Synchrotr, Shanghai 201800, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Fourth Mil Med Univ, Xian 710032, Shaanxi, Peoples R China; 4.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, L,Wang, KZ,Liu, JY,et al. Starvation effect on the morphology of microvilli in HeLa cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,514(4):1238—1243. |
| APA | Liu, L.,Wang, KZ.,Liu, JY.,Wei, YH.,Liu, WJ.,...&Li, B.(2019).Starvation effect on the morphology of microvilli in HeLa cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,514(4),1238—1243. |
| MLA | Liu, L,et al."Starvation effect on the morphology of microvilli in HeLa cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 514.4(2019):1238—1243. |
入库方式： OAI收割
来源：上海应用物理研究所
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