Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws
文献类型：期刊论文
| 作者 | Wang, ZR; Qin, WW; Zhuang, JL; Wu, MH; Li, Q; Fan, CH; Zhang, YQ |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:13页码:12244—12252 |
| ISSN号 | 1944-8244 |
| 关键词 | CIRCULATING TUMOR-CELLS ROLLING CIRCLE AMPLIFICATION HEPATITIS-B-VIRUS BREAST-CANCER NANOPARTICLES MECHANISMS EXPRESSION MICROCHIP SYSTEMS GROWTH |
| DOI | 10.1021/acsami.8b21998 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Synergy represents a natural approach for high-efficiency recognition in biological systems. Inspired by the recognition mechanism of viral infection of mammalian cells, here we develop heterovalency magnetic DNA nanoclaws with octopus arms morphology for synergetic cell capture. We demonstrated that the rigid flexible DNA nanoclaws can load multiple antibodies (Abs) targeting different epitopes for enhanced capture of cancer cells, especially significantly increasing the capture efficiency of MDA-MB-231 cells up to 82.3 +/- 7.1%. We also employed DNA nanoclaws with the combined use of multiple Abs to capture circulating tumor cells from clinical samples with high efficiency and specificity. We expect that the DNA nanoclaws not only could play a key role in liquid biopsy, but also could be expanded, with more applications benefiting from their modularity and programmability to modify various functionalities in future. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31899]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 2.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Immunol, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Div Phys Biol, Shanghai 201800, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai 201800, Peoples R China; 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; 6.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China; 7.South China Agriculatural Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, ZR,Qin, WW,Zhuang, JL,et al. Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(13):12244—12252. |
| APA | Wang, ZR.,Qin, WW.,Zhuang, JL.,Wu, MH.,Li, Q.,...&Zhang, YQ.(2019).Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws.ACS APPLIED MATERIALS & INTERFACES,11(13),12244—12252. |
| MLA | Wang, ZR,et al."Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws".ACS APPLIED MATERIALS & INTERFACES 11.13(2019):12244—12252. |
入库方式： OAI收割
来源：上海应用物理研究所
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