Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons
文献类型：期刊论文
| 作者 | Zhang, SH; Lv, F; Yuan, Y; Fan, CY; Li, J; Sun, WZ; Hu, J |
| 刊名 | FRONTIERS IN NEUROSCIENCE
 |
| 出版日期 | 2019 |
| 卷号 | 13期号:-页码:— |
| 关键词 | ANTERIOR CINGULATE CORTEX CORTICOTROPIN-RELEASING-FACTOR INTERNEURON DIVERSITY SERIES NUCLEUS BASALIS MOUSE MODEL SEROTONIN STRESS PAIN DORSAL DOPAMINE |
| ISSN号 | 1662-453X |
| DOI | 10.3389/fnins.2019.00565 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Corticotropin-releasing hormone (CRH) is a critical neuropeptide modulating the mammalian stress response. It is involved in many functional activities within various brain regions, among which there is a subset of CRH neurons occupying a considerable proportion of the cortical GABAergic interneurons. Here, we utilized rabies virus-based monosynaptic retrograde tracing system to map the whole-brain afferent presynaptic partners of the CRH neurons in the anterior cingulate cortex (ACC). We find that the ACC CRH neurons integrate information from the cortex, thalamus, hippocampal formation, amygdala, and also several other midbrain and hindbrain nuclei. Furthermore, our results reveal that ACC CRH neurons receive direct inputs from two neuromodulatory systems, the basal forebrain cholinergic neurons and raphe serotoninergic neurons. These findings together expand our knowledge about the connectivity of the cortical GABAergic neurons and also provide a basis for further investigation of the circuit function of cortical CRH neurons. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31902]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China; 6.Chinese Acad Sci, Inst Neurosci, Shanghai, Peoples R China; 7.Chinese Inst Brain Res, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, SH,Lv, F,Yuan, Y,et al. Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons[J]. FRONTIERS IN NEUROSCIENCE,2019,13(-):—. |
| APA | Zhang, SH.,Lv, F.,Yuan, Y.,Fan, CY.,Li, J.,...&Hu, J.(2019).Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.FRONTIERS IN NEUROSCIENCE,13(-),—. |
| MLA | Zhang, SH,et al."Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons".FRONTIERS IN NEUROSCIENCE 13.-(2019):—. |
入库方式： OAI收割
来源：上海应用物理研究所
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