Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539
文献类型：期刊论文
| 作者 | Li, Hong-Lei1,2,3 ; Li, Xiao-Ming1,2,3; Li, Xin1,2,3; Yang, Sui-Qun1,2,3; Wang, Bin-Gui1,2,3
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2019-08-01 |
| 卷号 | 32页码:138-142 |
| ISSN号 | 1874-3900 |
| 关键词 | Aspergillus terreus Laurencia okamurai Meroterpenoids Influenza neuraminidase inhibitor Antibacterial activity |
| DOI | 10.1016/j.phytol.2019.05.017 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Two new meroterpenoids, aperterpenes N (1) and O (2), along with two known structurally related derivatives, terretonins A (3) and G (4), were isolated and identified from the marine algal-derived endophytic fungus Aspergillus terreus EN-539. Their structures and absolute configurations were determined by a detailed interpretation of spectroscopic data and by X-ray crystallographic analysis. This is the first establishment of the absolute configurations for terretonins A (3) and G (4). Compound 1 showed inhibitory activity against influenza neuraminidase (IC50 = 18.0 nM), and compound 4 showed inhibitory activity against Micrococcus luteus and Staphylococcus aureus, with MIC values of 32 and 8 mu g/mL, respectively. |
| 资助项目 | National Natural Science Foundation of China[31330009] ; Natural Science Foundation of Shandong Province[ZR2018BD031] ; China Postdoctoral Science Foundation[2018M632732] ; Taishan Scholar Program from Shandong Province |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000476725000027 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/162771]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,et al. Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539[J]. PHYTOCHEMISTRY LETTERS,2019,32:138-142. |
| APA | Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,&Wang, Bin-Gui.(2019).Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539.PHYTOCHEMISTRY LETTERS,32,138-142. |
| MLA | Li, Hong-Lei,et al."Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539".PHYTOCHEMISTRY LETTERS 32(2019):138-142. |
入库方式： OAI收割
来源：海洋研究所
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