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Computed tomography-based predictive nomogram for differentiating primary progressive pulmonary tuberculosis from community-acquired pneumonia in children

文献类型：期刊论文

作者Wang, Bei1; Li, Min2,3; Ma, He2; Han, Fangfang2; Wang, Yan1; Zhao, Shunying4; Liu, Zhimin1; Yu, Tong1; Tian, Jie3,5; Dong, Di3,6
刊名BMC MEDICAL IMAGING
出版日期2019-08-08
卷号19期号:1页码:11
ISSN号1471-2342
关键词Child Tuberculosis Pulmonary Pneumonia Radiomics Nomogram
DOI10.1186/s12880-019-0355-z
通讯作者Dong, Di(di.dong@ia.ac.cn) ; Peng, Yun(ppengyun@hotmail.com)
英文摘要Background To investigate the value of predictive nomogram in optimizing computed tomography (CT)-based differential diagnosis of primary progressive pulmonary tuberculosis (TB) from community-acquired pneumonia (CAP) in children. Methods This retrospective study included 53 patients with clinically confirmed pulmonary TB and 62 patients with CAP. Patients were grouped at random according to a 3:1 ratio (primary cohort n = 86, validation cohort n = 29). A total of 970 radiomic features were extracted from CT images and key features were screened out to build radiomic signatures using the least absolute shrinkage and selection operator algorithm. A predictive nomogram was developed based on the signatures and clinical factors, and its performance was assessed by the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results Initially, 5 and 6 key features were selected to establish a radiomic signature from the pulmonary consolidation region (RS1) and a signature from lymph node region (RS2), respectively. A predictive nomogram was built combining RS1, RS2, and a clinical factor (duration of fever). Its classification performance (AUC = 0.971, 95% confidence interval [CI]: 0.912-1) was better than the senior radiologist's clinical judgment (AUC = 0.791, 95% CI: 0.636-0.946), the clinical factor (AUC = 0.832, 95% CI: 0.677-0.987), and the combination of RS1 and RS2 (AUC = 0.957, 95% CI: 0.889-1). The calibration curves indicated a good consistency of the nomogram. Decision curve analysis demonstrated that the nomogram was useful in clinical settings. Conclusions A CT-based predictive nomogram was proposed and could be conveniently used to differentiate pulmonary TB from CAP in children.
WOS关键词DIAGNOSIS ; CLASSIFICATION ; RADIOMICS
资助项目National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016YFA0100900] ; National Key R&D Program of China[2016YFA0100902] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; Beijing Natural Science Foundation[L182061] ; Bureau of International Cooperation of Chinese Academy of Sciences[173211KYSB20160053] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Open Foundation of The State Key Laboratory for Management and Control of Complex Systems[20170110] ; Youth Innovation Promotion Association CAS[2017175] ; Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority[XTCX201814]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者BMC
WOS记录号WOS:000480533000001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Bureau of International Cooperation of Chinese Academy of Sciences ; Instrument Developing Project of the Chinese Academy of Sciences ; Open Foundation of The State Key Laboratory for Management and Control of Complex Systems ; Youth Innovation Promotion Association CAS ; Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority
源URL[http://ir.ia.ac.cn/handle/173211/26347]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Dong, Di; Peng, Yun
作者单位1.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
2.Northeastern Univ, Sino Dutch Biomed & Informat Engn Sch, 3-11 Wenhua Rd, Shenyang, Liaoning, Peoples R China
3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Resp Med, 56 Nanlishi Rd, Beijing 100045, Peoples R China
5.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, 37 Xueyuan Rd, Beijing 100191, Peoples R China
6.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Bei,Li, Min,Ma, He,et al. Computed tomography-based predictive nomogram for differentiating primary progressive pulmonary tuberculosis from community-acquired pneumonia in children[J]. BMC MEDICAL IMAGING,2019,19(1):11.
APA Wang, Bei.,Li, Min.,Ma, He.,Han, Fangfang.,Wang, Yan.,...&Peng, Yun.(2019).Computed tomography-based predictive nomogram for differentiating primary progressive pulmonary tuberculosis from community-acquired pneumonia in children.BMC MEDICAL IMAGING,19(1),11.
MLA Wang, Bei,et al."Computed tomography-based predictive nomogram for differentiating primary progressive pulmonary tuberculosis from community-acquired pneumonia in children".BMC MEDICAL IMAGING 19.1(2019):11.

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来源：自动化研究所

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