Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)
文献类型：期刊论文
| 作者 | Dong,Di1,2,3 ; Zhang,Fan2,4; Zhong,Lian-Zhen1,3; Fang,Meng-Jie1,3; Huang,Cheng-Long2; Yao,Ji-Jin4; Sun,Ying2; Tian,Jie1,5; Ma,Jun2; Tang,Ling-Long2
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| 刊名 | BMC Medicine
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| 出版日期 | 2019-10-23 |
| 卷号 | 17期号:1 |
| ISSN号 | 1741-7015 |
| 关键词 | Individualized imaging biomarker Induction chemotherapy Survival benefit Treatment decision Locoregionally advanced nasopharyngeal cancer |
| DOI | 10.1186/s12916-019-1422-6 |
| 通讯作者 | Tian,Jie(jie.tian@ia.ac.cn) ; Ma,Jun(majun2@mail.sysu.edu.cn) ; Tang,Ling-Long(tangll@sysucc.org.cn) |
| 英文摘要 | AbstractBackgroundIn locoregionally advanced nasopharyngeal carcinoma (LANPC) patients, variance of tumor response to induction chemotherapy (ICT) was observed. We developed and validated a novel imaging biomarker to predict which patients will benefit most from additional ICT compared with chemoradiotherapy (CCRT) alone.MethodsAll patients, including retrospective training (n?=?254) and prospective randomized controlled validation cohorts (a substudy of NCT01245959, n?=?248), received ICT+CCRT or CCRT alone. Primary endpoint was failure-free survival (FFS). From the multi-parameter magnetic resonance images of the primary tumor at baseline, 819 quantitative 2D imaging features were extracted. Selected key features (according to their interaction effect between the two treatments) were combined into an Induction Chemotherapy Outcome Score (ICTOS) with a multivariable Cox proportional hazards model using modified covariate method. Kaplan-Meier curves and significance test for treatment interaction were used to evaluate ICTOS, in both cohorts.ResultsThree imaging features were selected and combined into ICTOS to predict treatment outcome for additional ICT. In the matched training cohort, patients with a high ICTOS had higher 3-year and 5-year FFS in ICT+CCRT than CCRT subgroup (69.3% vs. 45.6% for 3-year FFS, and 64.0% vs. 36.5% for 5-year FFS; HR?=?0.43, 95% CI?=?0.25–0.74, p?=?0.002), whereas patients with a low ICTOS had no significant difference in FFS between the subgroups (p?=?0.063), with a significant treatment interaction (pinteraction? |
| 语种 | 英语 |
| 出版者 | BioMed Central |
| WOS记录号 | BMC:10.1186/S12916-019-1422-6 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/26362]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Tian,Jie; Ma,Jun; Tang,Ling-Long |
| 作者单位 | 1. 2. 3. 4. 5. |
| 推荐引用方式 GB/T 7714 | Dong,Di,Zhang,Fan,Zhong,Lian-Zhen,et al. Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)[J]. BMC Medicine,2019,17(1). |
| APA | Dong,Di.,Zhang,Fan.,Zhong,Lian-Zhen.,Fang,Meng-Jie.,Huang,Cheng-Long.,...&Tang,Ling-Long.(2019).Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959).BMC Medicine,17(1). |
| MLA | Dong,Di,et al."Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)".BMC Medicine 17.1(2019). |
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来源：自动化研究所
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