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KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People

文献类型：期刊论文

作者Wang, Dawei1; Hu, Li1; Xu, Xinghua1; Ma, Xiangxing1; Li, Yi2; Liu, Yong3; Wang, Qing1; Zhuo, Chuanjun4
刊名JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
出版日期2019-11-01
卷号74期号:11页码:1725-1733
关键词KIBRA APOE Resting-state network Genetic interaction MRI
ISSN号1079-5006
DOI10.1093/gerona/glz004
通讯作者Zhuo, Chuanjun(chuanjunzhuotjmh@163.com)
英文摘要Genetic factors play a critical role in the development of Alzheimer's disease (AD). Kidney and brain expressed protein (KIBRA) and apolipoprotein E (APOE) are involved in episodic memory performance and AD. However, the interactions between KIBRA and APOE on brain functional network connectivity (FNC) remain unknown in healthy older people. Using independent component analysis, we systematically investigated additive and epistatic interactions of KIBRA rs1707045 and APOE on FNC in 170 healthy older Chinese people of Han ethnicity. We found significant additive KIBRA-APOE interactions on brain FNC in the right medial prefrontal cortex, the posterior cingulate cortex in the default-mode network, and the dorsal anterior cingulate cortex in the salience network. We also found significant epistatic KIBRA-APOE interactions on brain FNC in the left superior frontal gyrus and left angular gyrus in default-mode network. No significant KIBRA-APOE interactions were detected in other brain resting-state networks. These findings suggest that healthy older people have additive and epistatic interactions of KIBRA and APOE gene variants, which modulate brain FNC and may partly elucidate their association with episodic memory performance and AD.
WOS关键词INFLUENCES EPISODIC MEMORY ; APOLIPOPROTEIN-E GENOTYPE ; RESTING-STATE NETWORKS ; E TYPE-4 ALLELE ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; POLYMORPHISM ; ASSOCIATION ; RISK ; HIPPOCAMPUS
资助项目National Natural Science Foundation of China[81400890] ; National Natural Science Foundation of China[81571062] ; National Natural Science Foundation of China[81871052] ; Shandong Provincial Key Research and Development Program[2017GSF218093] ; Shandong Provincial Key Research and Development Program[2017CXGC1502] ; Shandong Provincial Key Research and Development Program[2017CXGC1504] ; Shandong Provincial Science and Technology Major Project (Emerging Industry)[2015ZDXX0801A01] ; Fundamental Research Funds of Shandong University[2017JC013] ; Key Projects of the Natural Science Foundation of Tianjin, China[17JCZDJC35700] ; Tianjin Health Bureau Foundation[2014KR02]
WOS研究方向Geriatrics & Gerontology
语种英语
WOS记录号WOS:000491242600006
出版者OXFORD UNIV PRESS INC
资助机构National Natural Science Foundation of China ; Shandong Provincial Key Research and Development Program ; Shandong Provincial Science and Technology Major Project (Emerging Industry) ; Fundamental Research Funds of Shandong University ; Key Projects of the Natural Science Foundation of Tianjin, China ; Tianjin Health Bureau Foundation
源URL[http://ir.ia.ac.cn/handle/173211/26622]  
专题自动化研究所_脑网络组研究中心
通讯作者Zhuo, Chuanjun
作者单位1.Shangdong Univ, Dept Radiol, Qilu Hosp, Jinan, Shandong, Peoples R China
2.Shangdong Univ, Dept Neurol, Qilu Hosp, Jinan, Shandong, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Tianjin Anding Hosp, Dept Psychiat Neuroimaging Genet & Comorbid Lab P, 13 Liulin Rd, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Dawei,Hu, Li,Xu, Xinghua,et al. KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(11):1725-1733.
APA Wang, Dawei.,Hu, Li.,Xu, Xinghua.,Ma, Xiangxing.,Li, Yi.,...&Zhuo, Chuanjun.(2019).KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(11),1725-1733.
MLA Wang, Dawei,et al."KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.11(2019):1725-1733.

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来源：自动化研究所

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