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Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors

文献类型：期刊论文

作者Tang, Jie1,2; Li, Yanjun1,2; Xu, Jiayuan1,2; Qin, Wen1,2; Su, Qian3,4; Xu, Qiang1,2; Liu, Bing5; Jiang, Tianzi5; Yu, Chunshui1,2
刊名BRAIN STRUCTURE & FUNCTION
出版日期2019-11-01
卷号224期号:8页码:2619-2630
关键词Allen human brain atlas COMT Functional connectivity density Functional magnetic resonance imaging Haplotype
ISSN号1863-2653
DOI10.1007/s00429-019-01924-7
通讯作者Yu, Chunshui(chunshuiyu@tmu.edu.cn)
英文摘要Catechol-O-methyltransferase (COMT) affects brain connectivity via modulating the dopamine system, with an expected greater effect of haplotypes than single-nucleotide polymorphism (SNP). The action pathway from COMT to dopamine to connectivity is theoretically dependent on the gene expression of dopamine receptors. Here, we aimed to investigate the impact of COMT haplotypes on brain functional connectivity density (FCD) in hundreds of healthy young subjects, and to disclose the association between the COMT-FCD statistical map and the spatial expression of the dopamine receptor genes. We found an inverted U-shaped modulation of COMT haplotypes on FCD in the left inferior parietal lobule that is mainly connected to the frontal and parietal cortices, with APS homozygotes exhibiting greater FCD than the other five groups. However, we failed to identify any significant effect of any SNP on FCD. Utilizing gene expression data collected from Allen human brain atlas, we found the COMT-FCD statistical map was significantly associated with the expression patterns of the dopamine receptor genes. Our results suggest that COMT haplotypes have greater impact on functional connectivity than a single genetic variation and that the association between COMT and functional connectivity may be dependent on the gene expression of dopamine receptors.
WOS关键词CATECHOL-O-METHYLTRANSFERASE ; GRAY-MATTER VOLUME ; MOTION ARTIFACT ; CONFOUND REGRESSION ; ICA-AROMA ; SCHIZOPHRENIA ; VARIANTS ; RISK ; POLYMORPHISM ; MODULATION
资助项目National Key Research and Development Program of China[2018YFC1314301] ; Natural Science Foundation of China[81425013] ; Natural Science Foundation of China[81501451] ; Natural Science Foundation of China[81301201]
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000489147300003
出版者SPRINGER HEIDELBERG
资助机构National Key Research and Development Program of China ; Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/26651]  
专题自动化研究所_脑网络组研究中心
通讯作者Yu, Chunshui
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China
3.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
5.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Tang, Jie,Li, Yanjun,Xu, Jiayuan,et al. Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors[J]. BRAIN STRUCTURE & FUNCTION,2019,224(8):2619-2630.
APA Tang, Jie.,Li, Yanjun.,Xu, Jiayuan.,Qin, Wen.,Su, Qian.,...&Yu, Chunshui.(2019).Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors.BRAIN STRUCTURE & FUNCTION,224(8),2619-2630.
MLA Tang, Jie,et al."Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors".BRAIN STRUCTURE & FUNCTION 224.8(2019):2619-2630.

入库方式： OAI收割

来源：自动化研究所

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