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White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study

文献类型：期刊论文

作者Cui Yue1,2,3; Dong Jiahao4; Yang Yongfeng5,6,7; Yu Hongyan5,6,7; Li Wenqiang5,6,7; Liu Yang4; Si Juanning4; Xie Sangma8; Sui Jing1,2,3,9; Lv Luxian5,6,7
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2020
卷号260页码:281-286
ISSN号0165-0327
DOI10.1016/j.jad.2019.09.029
通讯作者Lv Luxian(lvx928@126.com) ; Jiang Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Background: White matter abnormalities have been implicated in mental disorders including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ); however, the shared and distinct white matter integrity across mental disorders is still unclear. Methods: A total of 290 participants (MDD = 85, BD = 42, SZ = 68, and healthy controls = 95) were included in the present study. Tract-based spatial statistics were performed to measure fractional anisotropy (FA) and characterize shared and distinguishing white matter changes across mental disorders. Results: We found that decreased FA converged across MDD, BD and SZ in the body and genu of the corpus callosum, bilateral anterior and posterior corona radiata, and right superior corona radiata. By contrast, diagnosis-specific effect was only found in MDD in the anterior portion of anterior corona radiata. Limitations: The small and imbalanced sample size, and possible confounding effects of medication. Conclusions: Our findings suggest that abnormally reduced white matter integrity in the interhemispheric and thalamocortical circuit could be consistently involved in the pathogenesis of MDD, BD and SZ.
WOS关键词PSYCHIATRIC-DISORDERS ; ABNORMALITIES ; INTEGRITY ; IDENTIFICATION ; INVENTORY ; ANXIETY ; BURDEN ; SCALE ; MANIA
资助项目Natural Science Foundation of China[31771076] ; Natural Science Foundation of China[81671330] ; Open Program of Henan Key Laboratory of Biological Psychiatry[ZDSYS2018002] ; Cross Training (Shipei) Project of Beijing lnformation Science and Technology University ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC0904301] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Support Project for the Disciplinary Group of Psychology and Neuroscience, Xinxiang Medical University
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000490428300038
资助机构Natural Science Foundation of China ; Open Program of Henan Key Laboratory of Biological Psychiatry ; Cross Training (Shipei) Project of Beijing lnformation Science and Technology University ; High Scientific and Technological Research Fund of Xinxiang Medical University ; National Key Research and Development Program of China ; Medical Science and Technology Research Project of Henan Province ; Support Project for the Disciplinary Group of Psychology and Neuroscience, Xinxiang Medical University
源URL[http://ir.ia.ac.cn/handle/173211/26657]  
专题自动化研究所_脑网络组研究中心
通讯作者Lv Luxian; Jiang Tianzi
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Beijing Informat Sci & Technol Univ, Sch Instrumentat Sci & Optoelect Engn, Beijing, Peoples R China
5.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
6.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
7.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Henan, Peoples R China
8.Hangzhou Dianzi Univ, Coll Life Informat Sci & Instrument Engn, Hangzhou 310018, Zhejiang, Peoples R China
9.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
10.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
推荐引用方式
GB/T 7714		 Cui Yue,Dong Jiahao,Yang Yongfeng,et al. White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,260:281-286.
APA Cui Yue.,Dong Jiahao.,Yang Yongfeng.,Yu Hongyan.,Li Wenqiang.,...&Jiang Tianzi.(2020).White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study.JOURNAL OF AFFECTIVE DISORDERS,260,281-286.
MLA Cui Yue,et al."White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study".JOURNAL OF AFFECTIVE DISORDERS 260(2020):281-286.

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来源：自动化研究所

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