中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
River meander-inspired cross-section in 3D-printed helical microchannels for inertial focusing and enrichment

文献类型:期刊论文

作者Chen, Zezhou1; Zhao, Lei1; Wei, Lujie1; Huang, Ziyu2; Yin, Pengju1; Huang, Xiaowen2; Shi, Hongyan1,4; Hu, Bo1; Tian, Jie1,3
刊名SENSORS AND ACTUATORS B-CHEMICAL
出版日期2019-12-12
卷号301页码:9
关键词River meander-inspired cross-section 3D-printed microfluidics Inertial focusing and enrichment
DOI10.1016/j.snb.2019.127125
通讯作者Huang, Xiaowen(huangxiaowen2013@gmail.com) ; Hu, Bo(bohu@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Traditional microfluidic cross-sections are limited to several common geometries, which seriously imposes restrictions on the studies of flow fields and particle manipulations in microchannels. Fortunately, 3D printing technique is a versatile tool which can realize one-step fabrication of helical microchannels with various geometries and parameters. Inspired by the bed topography in river meanders, here, we report a novel 3D-printed river meander-like cross-section in helical microchannels for size-based inertial focusing and enrichment, aiming to realize more functional geometries as well as reduce the extensive laborious requirement in traditional fabrication process. This device can facilitate particle focusing at a larger scale than traditional channels. Compared to the circular, rectangular and trapezoidal channels, the river meander-like microfluidic channel can successfully realize 26 mu m particle focusing with a thinner focusing band in a shorter channel length. Also, in a single test, this structure can achieve 85.4% recovery and the enrichment ratio of 1.86 of spiked MDA-MB-231 cells in the whole blood, overcoming the dependence on traditional cell manipulation microfluidic devices. These results indicate that this 3D-printed river meander-like microfluidic chip has the great potential of size-based cell/particle sorting and enrichment for clinical application.
WOS关键词CIRCULATING TUMOR-CELLS ; LABEL-FREE ISOLATION ; ULTRA-FAST ; SEPARATION ; FLOW ; MICROFLUIDICS ; DEVICES
资助项目National Key Research and Development Program of China[2016YFC0102000] ; National Key Research and Development Program of China[2017YFA0205202] ; National Natural Science Foundation of China[81772011] ; National Natural Science Foundation of China[81601548] ; Natural Science Basic Research Plan in Shaanxi Province of China[2018JQ3027] ; China Postdoctoral Science Foundation[2018M633458] ; China Postdoctoral Science Foundation[2018M633475] ; 100 Talents Project of Shaanxi Province of China[SXBR9181] ; Fun-damental Research Funds for the Central Universities[JB161208] ; Fun-damental Research Funds for the Central Universities[JB171208]
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种英语
出版者ELSEVIER SCIENCE SA
WOS记录号WOS:000489529300076
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Basic Research Plan in Shaanxi Province of China ; China Postdoctoral Science Foundation ; 100 Talents Project of Shaanxi Province of China ; Fun-damental Research Funds for the Central Universities
源URL[http://ir.ia.ac.cn/handle/173211/26684]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Huang, Xiaowen; Hu, Bo; Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
2.Qilu Univ Technol, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Shandong, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Kunpad Commun Pty Ltd, Kunshan 215300, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Chen, Zezhou,Zhao, Lei,Wei, Lujie,et al. River meander-inspired cross-section in 3D-printed helical microchannels for inertial focusing and enrichment[J]. SENSORS AND ACTUATORS B-CHEMICAL,2019,301:9.
APA Chen, Zezhou.,Zhao, Lei.,Wei, Lujie.,Huang, Ziyu.,Yin, Pengju.,...&Tian, Jie.(2019).River meander-inspired cross-section in 3D-printed helical microchannels for inertial focusing and enrichment.SENSORS AND ACTUATORS B-CHEMICAL,301,9.
MLA Chen, Zezhou,et al."River meander-inspired cross-section in 3D-printed helical microchannels for inertial focusing and enrichment".SENSORS AND ACTUATORS B-CHEMICAL 301(2019):9.

入库方式: OAI收割

来源:自动化研究所

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