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Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect

文献类型：期刊论文

作者Du, Yang1,2,3; Jin, Yinhua4; Sun, Wei1,4; Fang, Junjie4; Zheng, Jianjun4; Tian, Jie1,2,3,4,5
刊名EUROPEAN RADIOLOGY
出版日期2019-08-01
卷号29期号:8页码:4294-4302
关键词Cancer Immunotherapy Molecular imaging Immune checkpoint target
ISSN号0938-7994
DOI10.1007/s00330-018-5814-3
通讯作者Zheng, Jianjun(zhjjnb2@163.com) ; Tian, Jie(tian@ieee.org)
英文摘要ObjectivesThis review describes the current status and progress of immune checkpoint targets for imaging of malignancies. Immune checkpoint blockade holds great potential for cancer treatment, and clinical implementation into routine is very rapidly progressing. Therefore, it is an urgent need to become familiar with the vocabulary of immunotherapy and with the evaluation of immune checkpoint and related treatments through noninvasive molecular imaging. Currently, immune target-associated imaging mainly includes PET, SPECT, optical imaging, and MRI. Each imaging method has its own inherent strengths and weaknesses in reflecting tumor morphology and physiology. PD-1, PD-L1, CTLA-4, and LAG-3 are the most commonly considered targets. In this review, the current status and progress of molecular imaging of immune checkpoint targets are discussed.ConclusionMolecular imaging is likely to become a major tool for monitoring immunotherapy. It can help in selecting patients who are suitable for immunotherapy, and also monitor the tumor response.Key Points center dot Immune checkpoint blockade holds great promise for the treatment of different malignant tumors.center dot Molecular imaging can identify the expression of immune checkpoint targets in the tumor microenvironment at the molecular and cellular levels, and therefore helps selecting potential responders, suitable for specific immunotherapy.center dot Molecular imaging can also monitor immunotherapeutic effects, and therefore participates in the evaluation of tumor response to treatment.
WOS关键词PD-L1 EXPRESSION ; INFILTRATING LYMPHOCYTES ; CANCER-IMMUNOTHERAPY ; RADIOTRACER ; INHIBITORS ; BLOCKADE ; ANTIBODY
资助项目Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2106YFC0103702] ; Ministry of Science and Technology of China[2016YFA0201401] ; Ministry of Science and Technology of China[2015CB755500] ; Ministry of Science and Technology of China[2014CB748600] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81470083] ; Bei jing Municipal Science and Technology Commission[Z161100002616022] ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province[WKJ-ZJ-1807] ; Key R&D project of Zhejiang Province[2017C03042] ; Public Welfare Technology Application Research Project of Zhejiang Province[2017C35003] ; Key Scientific and Technological Special Project of Ningbo City[2015C50004]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000473737100037
出版者SPRINGER
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Bei jing Municipal Science and Technology Commission ; Science Research Fund of National Health and Family Planning Commission-Major Project of Medical and Health Science and Technology in Zhejiang Province ; Key R&D project of Zhejiang Province ; Public Welfare Technology Application Research Project of Zhejiang Province ; Key Scientific and Technological Special Project of Ningbo City
源URL[http://ir.ia.ac.cn/handle/173211/26834]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Zheng, Jianjun; Tian, Jie
作者单位1.Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Ningbo 2 Hosp, Dept Radiol, Xibei St 41, Ningbo 315010, Zhejiang, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yang,Jin, Yinhua,Sun, Wei,et al. Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect[J]. EUROPEAN RADIOLOGY,2019,29(8):4294-4302.
APA Du, Yang,Jin, Yinhua,Sun, Wei,Fang, Junjie,Zheng, Jianjun,&Tian, Jie.(2019).Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect.EUROPEAN RADIOLOGY,29(8),4294-4302.
MLA Du, Yang,et al."Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect".EUROPEAN RADIOLOGY 29.8(2019):4294-4302.

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来源：自动化研究所

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