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Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study

文献类型：期刊论文

作者Fu, Sirui1,10; Wei, Jingwei1,2; Zhang, Jie3; Dong, Di1,2; Song, Jiangdian1,2; Li, Yong10; Duan, Chongyang4; Zhang, Shuaitong1,2; Li, Xiaoqun5; Gu, Dongsheng1,2
刊名CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
出版日期2019-08-01
卷号10页码:12
ISSN号2155-384X
DOI10.14309/ctg.0000000000000070
通讯作者Tian, Jie(tian@ieee.org) ; Lu, Ligong(llg0902@sina.com)
英文摘要OBJECTIVES: Models should be developed to assist choice between liver resection (LR) and transarterial chemoembolization (TACE) for hepatocellular carcinoma. METHODS: After separating 520 cases from 5 hospitals into training (n = 302) and validation (n = 218) data sets, we weighted the cases to control baseline difference and ensured the causal effect between treatments (LR and TACE) and estimated progression-free survival (PFS) difference. A noninvasive PFS model was constructed with clinical factors, radiological characteristics, and radiomic features. We compared our model with other 4 state-of-the-art models. Finally, patients were classified into subgroups with and without significant PFS difference between treatments. RESULTS: Our model included treatments, age, sex, modified Barcelona Clinic Liver Cancer stage, fusion lesions, hepatocellular carcinoma capsule, and 3 radiomic features, with good discrimination and calibrations (area under the curve for 3-year PFS was 0.80 in the training data set and 0.75 in the validation data set; similar results were achieved in 1- and 2-year PFS). The model had better accuracy than the other 4 models. A nomogram was built, with different scores assigned for LR and TACE. Separated by the threshold of score difference between treatments, for some patients, LR provided longer PFS and might be the better option (training: hazard ratio [HR] = 0.50, P= 0.014; validation: HR = 0.52, P= 0.026); in the others, LR provided similar PFS with TACE (training: HR = 0.84, P = 0.388; validation: HR = 1.14, P = 0.614). TACE may be better because it was less invasive. DISCUSSION: We propose an individualized model predicting PFS difference between LR and TACE to assist in the optimal treatment choice.
WOS关键词RADIOFREQUENCY ABLATION ; SURGICAL RESECTION ; SURVIVAL ; SORAFENIB ; OUTCOMES ; UPDATE
资助项目National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1308701] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016CZYD0001] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501549] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Youth Innovation Promotion Association CAS
WOS研究方向Gastroenterology & Hepatology
语种英语
出版者LIPPINCOTT WILLIAMS & WILKINS
WOS记录号WOS:000487054100001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences ; Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Youth Innovation Promotion Association CAS
源URL[http://ir.ia.ac.cn/handle/173211/27004]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Lu, Ligong
作者单位1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Jinan Univ, Dept Radiol, Zhuhai Peoples Hosp, Zhuhai Hosp, Zhuhai, Peoples R China
4.Southern Med Univ, Dept Biostat, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China
5.Zhongshan City Peoples Hosp, Dept Intervent Treatment, Zhongshan, Peoples R China
6.Shenzhen Peoples Hosp, Dept Radiol, Shenzhen, Peoples R China
7.Southern Med Univ, Intervent Diag & Treatment Dept, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
8.Yangiang Peoples Hosp, Dept Radiol, Yangjiang, Peoples R China
9.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China
10.Jinan Univ, Zhuhai Intervent Med Ctr, Zhuhai Precis Med Ctr, Zhuhai Peoples Hosp, Zhuhai, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Sirui,Wei, Jingwei,Zhang, Jie,et al. Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study[J]. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY,2019,10:12.
APA Fu, Sirui.,Wei, Jingwei.,Zhang, Jie.,Dong, Di.,Song, Jiangdian.,...&Lu, Ligong.(2019).Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study.CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY,10,12.
MLA Fu, Sirui,et al."Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study".CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY 10(2019):12.

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来源：自动化研究所

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