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Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer

文献类型：期刊论文

作者Fan, Li1; Fang, MengJie2,3; Tu, WenTing1; Zhang, Di1; Wang, Yun1; Zhou, Xiuxiu1; Xia, Yi1; Li, ZhaoBin4; Liu, ShiYuan1
刊名ACADEMIC RADIOLOGY
出版日期2019-09-01
卷号26期号:9页码:1253-1261
ISSN号1076-6332
关键词Lung Nonsmall cell lung cancer Tomography X-ray computed Computational biology Prognosis
DOI10.1016/j.acra.2018.11.004
通讯作者Li, ZhaoBin(lizhaobin79@163.com) ; Liu, ShiYuan(lsy0930@163.com)
英文摘要Objectives: To evaluate the predictive value of radiomics features on the distant metastasis (DM) of stage I nonsmall cell lung cancer (NSCLC) preoperatively, by comparing with clinical characteristics and CT morphological features, and to screen the important prognostic predictors. Methods: One hundred ninety-four stage I NSCLC patients were retrospectively enrolled, DM free survival (DMFS) was evaluated. The consensus clustering analysis was used to build the radiomics signatures in the primary cohort and validated in the validation cohort. The univariate survival analysis was performed in clinical characteristics, CT morphological features and radiomics signatures, respectively. Cox model was performed and C-index was calculated. Results: There were 25 patients (12.9%) with DM. The median DMFS was 15 months. Three hundred thirteen radiomics features were selected, then classified into five groups, two subtypes (I and II) with each group. The RS1 showed the best prognostic ability with C-index of 0.355(95% confidence interval [CI], 0.269-0.442; p < 0.001). The histological type exhibited a good prognostic ability with C-index of 0.123 (95% CI, 0.000-0.305; p < 0.001) for DMFS. Cox model showed RS1(hazard ratio [HR] 18.025, 95% CI 2.366-137.340), pleural indentation sign (HR 2.623, 95% CI 1.070-6.426) and histological type (HR 4.461, 95% CI 1.783-11.162) were the independent prognostic factors (p < 0.05). Conclusion: Radiomics provided a new modality for the distant metastatic prediction of stage I NSCLC. Patients with type II of RS1, pleural indentation sign and nonadenocarcinoma indicated the high probability of postsurgical DM.
WOS关键词TUMOR HETEROGENEITY ; TNM CLASSIFICATION ; PROGNOSTIC VALUE ; 8TH EDITION ; FEATURES ; REPRODUCIBILITY ; GROUPINGS ; REVISION ; NODULES
资助项目National Key R&D Program of China[2016YFE0103000] ; National Key R&D Program of China[2017YFC1308703] ; National Natural Science Foundation of China[81871321] ; National Natural Science Foundation of China[81370035] ; Youth Fund of the National Natural Science Foundation of China[81501618]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000482544300017
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Youth Fund of the National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/27244]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Li, ZhaoBin; Liu, ShiYuan
作者单位1.Second Mil Med Univ, Changzheng Hosp, Dept Radiol, 415 Fengyang Rd, Shanghai 200233, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiat Oncol, 600 Yishan Rd, Shanghai 200233, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Li,Fang, MengJie,Tu, WenTing,et al. Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer[J]. ACADEMIC RADIOLOGY,2019,26(9):1253-1261.
APA Fan, Li.,Fang, MengJie.,Tu, WenTing.,Zhang, Di.,Wang, Yun.,...&Liu, ShiYuan.(2019).Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer.ACADEMIC RADIOLOGY,26(9),1253-1261.
MLA Fan, Li,et al."Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer".ACADEMIC RADIOLOGY 26.9(2019):1253-1261.

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来源：自动化研究所

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