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High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors

文献类型：期刊论文

作者Meng, Lingchen1; Ma, Xibo2,3; Jiang, Shan1; Ji, Guang1; Han, Wenkun1; Xu, Bin1; Tian, Jie2,3; Tian, Wenjing1
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2019-09-21
卷号7期号:35页码:5345-5351
ISSN号2050-750X
DOI10.1039/c9tb00638a
通讯作者Tian, Jie() ; Tian, Wenjing(wjtian@jlu.edu.cn)
英文摘要High-quality multimodal imaging requires exogenous contrast agents with high sensitivity, spatial-temporal resolution, and high penetration depth for the accurate diagnosis and surveillance of cancer. Herein, we design a highly efficient fluorescent and magnetic multimodal probe by doping fluorescent molecule 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB) with near-infrared (NIR) fluorescent emission (714 nm) and superparamagnetic iron oxide (SPIO) into a polystyrene-polyethylene glycol (PS-PEG) matrix to form TB/SPIO@PS-PEG nanoparticles (TSP NPs). The as-prepared TSP NPs exhibit red aggregation-induced emission (AIE) with a maximum wavelength at 655 nm and high fluorescence quantum yield (QY) of 14.6%, facilitating the improvement of sensitivity and signal-to-background ratio for fluorescence molecular imaging (FMI). Phase behavior investigation of the TB/SPIO@PS-PEG probe system by Flory-Huggins lattice theory elucidates the highly efficient fluorescence of the multimodal probe, originating from the poor miscibility between TB and SPIO. Meanwhile, the TSP NPs possess good superparamagnetism and relaxivity and can thus be used as appropriate magnetic contrast agents for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). In addition, the good biocompatibility and photostability of the TSP NPs make them suitable for long-term monitoring. In vivo fluorescence imaging results indicate that the TSP NPs can facilitate monitoring of subcutaneous tumor growth for more than 24 days in a real-time manner. Multimodal imaging consisting of FMI, MRI, and MPI reveals that TSP NPs can monitor a liver tumor in situ with almost unlimited depth in tissues and high temporal-spatial resolution. As a multimodal probe, the TSP NPs manifest obvious synergistic advantages of long-term monitoring and high penetration depth and hold great prospects in tumor imaging.
WOS关键词AGGREGATION-INDUCED EMISSION ; TURN-ON DETECTION ; NANOPARTICLES ; MISCIBILITY ; AGENT
资助项目Natural Science Foundation of China[21835001] ; Natural Science Foundation of China[21674041] ; Natural Science Foundation of China[51773080] ; Natural Science Foundation of China[51573068] ; Natural Science Foundation of China[21221063] ; Natural Science Foundation of China[81871442] ; National Key Research programs of China[2016YFA0100900] ; National Key Research programs of China[2016YFA0100902] ; National Key Research programs of China[2017YFA0205200] ; Program for Changbaishan Scholars of Jilin Province ; ''Talents Cultivation Program'' of Jilin University ; Jilin Province project[20160101305JC]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000486046100007
出版者ROYAL SOC CHEMISTRY
资助机构Natural Science Foundation of China ; National Key Research programs of China ; Program for Changbaishan Scholars of Jilin Province ; ''Talents Cultivation Program'' of Jilin University ; Jilin Province project
源URL[http://ir.ia.ac.cn/handle/173211/27284]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Tian, Wenjing
作者单位1.Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Meng, Lingchen,Ma, Xibo,Jiang, Shan,et al. High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(35):5345-5351.
APA Meng, Lingchen.,Ma, Xibo.,Jiang, Shan.,Ji, Guang.,Han, Wenkun.,...&Tian, Wenjing.(2019).High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors.JOURNAL OF MATERIALS CHEMISTRY B,7(35),5345-5351.
MLA Meng, Lingchen,et al."High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors".JOURNAL OF MATERIALS CHEMISTRY B 7.35(2019):5345-5351.

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来源：自动化研究所

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