Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics
文献类型：期刊论文
| 作者 | Lv, Ruichan1; Feng, Miao1; Liu, Jun1; Jiang, Xue1; Yuan, Huijuan1; Yan, Ruyu1; Tian, Jie1,2
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| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
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| 出版日期 | 2019-09-01 |
| 卷号 | 5期号:9页码:4683-4691 |
| 关键词 | up conversion luminescence short wavelength infrared photoacoustic multimodal imaging lanthanide nanoparticles |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.9b00688 |
| 通讯作者 | Lv, Ruichan(rclv@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
| 英文摘要 | In this research, a multimodal imaging platform guided photodynamic theranostics under 808 nm was designed using a NaErF4:Tm@NaYF4:Yb@NaLuF4:Nd,Yb-ZnPc structure. Unlike conventional codoped Yb3+/Er3+ system, Er3+ ions as activator and sensitizer were used to improve the up-conversion energy transfer processes. Furthermore, higher energy transfer processes between Er3+ ions could be obtained through doped 1% Tm3+ ions as an energy trapping center in the NaErF4. This platform could emit much brighter upconversion luminescence (UCL) (124-fold enhancement for red emission) and short wavelength infrared (SWIR) emission under single 808 nm laser excitation. Importantly, the SWIR imaging with higher resolution and better signal-to-noise ratio can pass the blood-brain barrier to see the brain vessels. Because of the enhanced red emission, the UCL nanoparticles were combined with ZnPc agent to exhibit photodynamic therapy (PDT) effect, and its distribution and excretion could be detected by the photoacoustic (PA) imaging under single near-infrared (NIR) laser. Thus, this platform could be used as multimodal imaging (SWIR, PA, CT, and UCL) guided PDT agent under single 808 nm laser. |
| WOS关键词 | UP-CONVERSION NANOPARTICLES ; PHOTON-UPCONVERTING NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ENERGY-TRANSFER ; IN-VIVO ; SINGLE ; NANOCRYSTALS ; STRATEGY ; NANOSTRUCTURES ; EXCITATION |
| 资助项目 | Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000485210900048 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ia.ac.cn/handle/173211/27288]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Lv, Ruichan; Tian, Jie |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Ruichan,Feng, Miao,Liu, Jun,et al. Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(9):4683-4691. |
| APA | Lv, Ruichan.,Feng, Miao.,Liu, Jun.,Jiang, Xue.,Yuan, Huijuan.,...&Tian, Jie.(2019).Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(9),4683-4691. |
| MLA | Lv, Ruichan,et al."Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.9(2019):4683-4691. |
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来源：自动化研究所
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